110298-78-7Relevant articles and documents
A Br?nsted Acid Catalyzed Cascade Reaction for the Conversion of Indoles to α-(3-Indolyl) Ketones by Using 2-Benzyloxy Aldehydes
Banerjee, Ankush,Maji, Modhu Sudan
supporting information, p. 11521 - 11527 (2019/08/16)
A Br?nsted acid catalyzed, operationally simple, scalable route to several functionalized α-(3-indolyl) ketones has been developed and the long-standing regioisomeric issue has been eliminated by choosing appropriate carbonyls. A readily available and cheap bottle reagent was used as the catalyst. This protocol was also applicable to the synthesis of densely functionalized α-(3-pyrrolyl) ketones. A detailed mechanistic study confirmed the involvement of enolether as a reaction intermediate. Several postsynthetic modifications along with easy access to β-carboline, tryptamines, tryptophols, and spiro-indolenine proclaim the synthetic utility of this powerful building block. On the basis of this concept, functionalized carbazoles were constructed by a cascade annulation strategy.
Asymmetric synthesis of β-hydroxy acid via stereoselective dirhodium(II)-catalyzed C-H insertion of α-alkoxydiazoketone
Yakura, Takayuki,Tanaka, Takeshi,Ikeda, Masazumi,Uenishi, Jun'ichi
, p. 471 - 473 (2007/10/03)
A new methodology for the asymmetric synthesis of β-hydroxy acid was developed. Dirhodium(II)-catalyzed C-H insertion of α-alkoxydiazoketone (3), which was prepared from primary alkyl halide (1) and readily available chiral α-hydroxy acid (2), gave stereo
Synthesis of derivatives of (2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoic acid, a constituent of the didemnins
Gonzalez, Isabel,Jou, Gemma,Caba, Josep Maria,Albericio, Fernando,Lloyd-Williams, Paul,Giralt, Ernest
, p. 1427 - 1433 (2007/10/03)
The syntheses of the two protected derivatives 7 and 16 of (2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoic acid, a constituent of the didemnin family of antineoplastic macrocyclic depsipeptides are described. The preparation of 7 was carried out by modificat
