110327-46-3Relevant academic research and scientific papers
Reconstructed hydrotalcite as a highly active heterogeneous base catalyst for carbon-carbon bond formations in the presence of water
Ebitani, Kohki,Motokura, Ken,Mori, Kohsuke,Mizugaki, Tomoo,Kaneda, Kiyotomi
, p. 5440 - 5447 (2007/10/03)
The aldol reaction of carbonyl compounds is efficiently catalyzed by reconstructed hydrotalcites, obtained by treating the Mg-Al mixed oxide with water, as solid base catalysts in the presence of water. The catalysis of the reconstructed hydrotalcites is attributable to the surface base sites, created during the organization of the layered structure, with uniformly distributed strength. Furthermore, the reconstructed hydrotalcites provide a unique acid-base bifunctional surface capable of promoting the Knoevenagel and Michael reactions of nitriles with carbonyl compounds.
Practical synthesis of chiral emopamil left hand as a bioactive motif.
Kimura, Teiji,Yamamoto, Noboru,Suzuki, Yuichi,Kawano, Koki,Norimine, Yoshihiko,Ito, Koichi,Nagato, Satoshi,Iimura, Yoichi,Yonaga, Masahiro
, p. 6228 - 6231 (2007/10/03)
An asymmetric synthesis of (2S)-2-(2-isopropyl)-5-hydroxy-2-phenylpentanenitrile (emopamil left hand, 2) has been completed by use of the MAD (methyl aluminum bis(4-methyl-2,6-di-tert-butylphenoxide)-induced rearrangement of a chiral epoxyalcohol as the key reaction. The stereochemistry of the chiral quaternary center was confirmed by transformation of 2 to (S)-noremopamil. This method requires minimal purification procedures and affords high chemical and optical yields. Acid-catalyzed isomerization of an allylaldehyde and retro-aldol type racemization at the quaternary carbon of a nitrile-alcohol were encountered.
