110345-80-7

Basic information

• Product Name: 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-(2-oxo-2-phenylethyl) ester, (S)-
• CAS NO: 110345-80-7
• Molecular Formula: C18H23NO5
• Molecular Weight: 333.384
• Mol File: 110345-80-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-(2-oxo-2-phenylethyl) ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-(2-oxo-2-phenylethyl) ester, (S)-(110345-80-7)
• EPA Substance Registry System: 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-(2-oxo-2-phenylethyl) ester, (S)-(110345-80-7)

Safety Data

• Hazardous Substances Data: 110345-80-7(Hazardous Substances Data)

Upstream product

• 70-11-1 α-bromoacetophenone 
• 147-85-3 L-proline 
• 98-86-2 acetophenone 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 154561-18-9 Boc-L-MePhe-L-Pro-OPac 
• 154524-86-4 Boc-L-Phe-L-MePhe-L-Pro-OPac 
• 154524-87-5 Boc-L-MeVal-L-Phe-L-MePhe-L-Pro-OPac 
• 127785-64-2 aureobasidin A 
• 1252037-59-4 (S)-2-(5-phenyl-1H-imidazol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1616704-88-1 2,2-dimethyl-5-oxo-5-(((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-3a-((S)-2-(5-phenyl-1H-imidazol-2-yl)pyrrolidine-1-carbonyl)-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yl)oxy)pentanoic acid 
• 1616705-50-0 (1S,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3a-((S)-2-(5-phenyl-1H-imidazol-2-yl)pyrrolidine-1-carbonyl)icosahydro-1H-cyclopenta[a]chrysen-9-yl acetate 
• 1616705-51-1 ((1S,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-1-isopropyl-5a,5b,8,8,11a-pentamethylicosahydro-3aH-cyclopenta[a]chrysen-3a-yl)((S)-2-(5-phenyl-1H-imidazol-2-yl)pyrrolidin-1-yl)methanone 
• 1616705-52-2 1-benzyl 3-((1S,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3a-((S)-2-(5-phenyl-1H-imidazol-2-yl)pyrrolidine-1-carbonyl)icosahydro-1H-cyclopenta[a]chrysen-9-yl)(1R,3S)-2,2-dimethylcyclobutane-1,3-dicarboxylate 
• 1616704-90-5 (1R,3S)-3-((((1S,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3a-((S)-2-(5-phenyl-1H-imidazol-2-yl)pyrrolidine-1-carbonyl)icosahydro-1H-cyclopenta[a]chrysen-9-yl)oxy)carbonyl)-2,2-dimethylcyclobutane-1-carboxylic acid 

Relevant articles and documents

NOVEL BETULINIC PROLINE IMIDAZOLE DERIVATIVES AS HIV INHIBITORS

The present invention relates to novel betulinic proline imidazole derivatives and related compounds, compositions useful for therapeutic treatment of viral diseases and particularly HIV mediated diseases.

Synthesis and evaluation of non-dimeric HCV NS5A inhibitors

Based on the symmetrical bidentate structure of the NS5A inhibitor BMS-790052, a series of new monodentate molecules were designed. The synthesis of 36 new non-dimeric NS5A inhibitors is reported along with their ability to block HCV replication in an HCV 1b replicon system. Among them compound 5a showed picomolar range activity along with an excellent selectivity index (SI > 90,000).

ONE POT SYNTHESIS AND CONFORMATION OF N-t-BUTYLOXYCARBONYL, O-PHENACYL DERIVATIVES OF PROLINE AND OTHER SECONDARY AMINO ACIDS.

Proline, 4-hydroxyproline, azetidine-2-carboxylic acid, pipecolic acid and proline containing dipeptides were converted to N-t-butyloxycarbonyl, O-phenacyl derivatives in a one pot synthesis. 1H- and 13C-NMR spectroscopy of certain derivatives (Boc-Pro-PE