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1103524-20-4

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1103524-20-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1103524-20-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,0,3,5,2 and 4 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1103524-20:
(9*1)+(8*1)+(7*0)+(6*3)+(5*5)+(4*2)+(3*4)+(2*2)+(1*0)=84
84 % 10 = 4
So 1103524-20-4 is a valid CAS Registry Number.

1103524-20-4Downstream Products

1103524-20-4Relevant academic research and scientific papers

Discovery of diacylphloroglucinols as a new class of GPR40 (FFAR1) agonists

Bharate, Sandip B.,Rodge, Atish,Joshi, Rajendra K.,Kaur, Jaspreet,Srinivasan, Shaila,Senthil Kumar,Kulkarni-Almeida, Asha,Balachandran, Sarala,Balakrishnan, Arun,Vishwakarma, Ram A.

scheme or table, p. 6357 - 6361 (2009/10/01)

In this letter, we report discovery of diacylphloroglucinol compounds as a new class of GPR40 (FFAR1) agonists. Several diacylphloroglucinols with varying length of acyl functionality and substitution on aromatic hydroxyls were synthesized and evaluated for GPR40 agonism using functional calcium-flux assay. Out of 17 compounds evaluated, 14, 17, 19 and 25 exhibited good GPR40 agonistic activity with EC50 values ranging from 0.07 to 8 μM (pEC50 7.12-5.09), respectively, with maximal agonistic response of 84-102%.

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