19759-26-3

Upstream product

• 2039-85-2 3-Chlorostyrene 
• 64-19-7 acetic acid 
• 120121-01-9 1-(m-Chlorophenyl)ethanol 
• 108-24-7 acetic anhydride 
• 22391-00-0 α-Acetoxy-m-chloro-styrol 
• 540-88-5 acetic acid tert-butyl ester 

Downstream Products

• 120121-01-9 1-(m-Chlorophenyl)ethanol 
• 1610950-01-0 1-chloro-3-(1-(o-tolyl)ethyl)benzene 
• 882753-05-1 1-chloro-3-(1-(p-tolyl)ethyl)benzene 
• 1103679-61-3 (S)-1-(3-chlorophenyl)ethanol acetate 
• 120121-01-9 (R)-1-(3-chlorophenyl)-ethanol 

Relevant academic research and scientific papers

KMnO4-catalyzed chemoselective deprotection of acetate and controllable deacetylation-oxidation in one pot

A novel and efficient protocol for chemoselective deacetylation under ambient conditions was developed using catalytic KMnO4. The stoichiometric use of KMnO4 highlighted the dual role of a heterogeneous oxidant enabling direct access to aromatic aldehydes in one-pot sequential deacetylation-oxidation. The reaction employed an alternative solvent system and allowed the clean transformation of benzyl acetate to sensitive aldehyde in a single step while preventing over-oxidation to acids. Use of inexpensive and readily accessible KMnO4 as an environmentally benign reagent and the ease of the reaction operation were particularly attractive, and enabled the controlled oxidation and facile cleavage of acetate in a preceding step. This journal is

Base-catalyzed selective esterification of alcohols with unactivated esters

A practical and efficient base-catalyzed esterification has been developed for the facile synthesis of a broad range of esters from simple alcohols with unactivated tert-butyl esters. This protocol could be conducted at mild conditions, providing esters in high to excellent yields with good functional tolerance. Mechanistic studies provided evidence of an exchange of the tert-butyl alkoxide metal with the alcohol, producing a new alkoxide to participate in the transesterification reaction.

Baeyer-Villiger monooxygenase-catalyzed kinetic resolution of racemic α-alkyl benzyl ketones: enzymatic synthesis of α-alkyl benzylketones and α-alkyl benzylesters

The application of three BVMOs for the enantioselective oxidation of 3-phenylbutan-2-ones with different substituents in the aromatic moiety is described. By choosing the appropriate biocatalyst and substrate combination, chiral ketones and esters can be obtained with excellent enantiopurities. This methodology could also be applied to the resolution of racemic α-alkyl benzylketones with longer alkyl chains as well as with two substituted α-substituted benzylacetones. A kinetic analysis revealed that the BVMOs studied effectively convert all tested compounds showing that the enzymes are tolerant towards the substrate structure while being highly enantioselective. These properties render BVMOs as valuable biocatalysts for the preparation of compounds with high interest in organic synthesis.

Immobilized Manihot esculenta preparation as a novel biocatalyst in the enantioselective acetylation of racemic alcohols

The enzymatic preparation obtained from a discard of Manihot esculenta roots has been successfully immobilized on calcium alginate hydrogels. This preparation has been tested as a chiral biocatalyst in the enzymatic acylation of a set of racemic aromatic alcohols. Depending on the reaction conditions, excellent enantioselectivities can be achieved. Some parameters that can alter the biocatalytic properties of the enzyme, such as solvent, temperature, acyl donor and substrate structure have been studied exhaustively in order to establish a deeper knowledge of this novel biocatalyst.

ESTERIFICACION DE DERIVADOS DE ESTIRENO CON ACIDO ACETICO EN PRESENCIA DE ACIDO PERCLORICO COMO CATALIZADOR

The present work is focused to develop the production of esters from derivatives of styrene by acetic acid using perchloric acid as a catalyst.The kinetics of the reaction was studied and analysis of the variables was carried out.Key words: Esterification, styrene, perchloric, acid, acetic acid.