1104077-72-6Relevant academic research and scientific papers
PIPERIDINE DERIVATIVES AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7
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Page/Page column 128, (2018/05/16)
The present invention concerns the identification of inhibitors of ubiquitin specific protease 7 (USP7), and methods of use thereof.
Catalytic asymmetric hydrogenation of α-CF3- or β-CF3-Substituted acrylic acids using Rhodium(I) complexes with a combination of chiral and achiral ligands
Dong, Kaiwu,Li, Yang,Wang, Zheng,Ding, Kuiling
supporting information, p. 14191 - 14195 (2014/01/06)
Only the mixture works! Acrylic acid derivatives with CF3 substituents in α or β position were efficiently hydrogenated in the presence of a RhI complex with a chiral secondary phosphine oxide (SPO; see scheme) and an achiral Ph3P as ligands. The corresponding propanoic acid derivatives were obtained with generally high conversion (>99 %) and high enantioselectivity (92->99 %). Copyright
Practical enantioselective synthesis of a 3-aryl-3-trifluoromethyl-2- aminopropanol derivative
Alimardanov, Asaf,Nikitenko, Antonia,Connolly, Terrence J.,Feigelson, Gregg,Chan, Anita W.,Ding, Zhixian,Ghosh, Mousumi,Shi, Xinxu,Ren, Jianxin,Hansen, Eric,Farr, Roger,MacEwan, Michael,Tadayon, Sam,Springer, Dane M.,Kreft, Anthony F.,Ho, Douglas M.,Potoski, John R.
experimental part, p. 1161 - 1168 (2010/04/22)
Development of a large-scale enantioselective synthesis of a lead compound containing a 3-aryl-3-trifluoromethyl-2-aminopropanol core is described. A single isomer of 3,3-disubstituted acrylic acid derivative was prepared via Perkin condensation or Horner
PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF HETEROCYCLIC SULFONAMIDE COMPOUNDS
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Page/Page column 22, (2009/02/11)
Methods for preparing compound of formula (I) are described, wherein R1-R3 are defined herein, as are methods for preparing the intermediates formed therein. Also described are methods for enantioselectively preparing a chiral compou
PROCESS FOR THE PREPARATION OF TRIFLUOROALKYL-PHENYL AND HETEROCYCLIC SULFONAMIDES
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Page/Page column 13, (2009/02/11)
A novel trifluoroacetylating agent, i.e., N-trifluoroacetylmorpholine, is described. This reagent is useful in the preparation of phenyl and heterocyclic sulfonamide compounds. Methods are therefore described for preparing sulfonamide compounds of the fol
