845823-12-3

Basic information

• Product Name: 2,2,2,3',5'-PENTAFLUOROACETOPHENONE
• Synonyms: 1,1,1,3',5'-PENTAFLUOROACETOPHENONE;1-(3,5-DIFLUORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE;2,2,2,3',5'-PENTAFLUOROACETOPHENONE;1-(3,5-Difluoro-pehnyl)-2,2,2-trifluoro-ethanone;1-(3,5-difluorophenyl)-2,2,2-trifluoroethan-1-one;3',5'-Difluoro-2,2,2-trifluoroacetophenone
• CAS NO: 845823-12-3
• Molecular Formula: C₈H₃F₅O
• Molecular Weight: 210.1
• Product Categories: Fluorine series
• Mol File: 845823-12-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,2,2,3',5'-PENTAFLUOROACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2,3',5'-PENTAFLUOROACETOPHENONE(845823-12-3)
• EPA Substance Registry System: 2,2,2,3',5'-PENTAFLUOROACETOPHENONE(845823-12-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25
• Hazardous Substances Data: 845823-12-3(Hazardous Substances Data)

Usage

General Description

2,2,2,3',5'-Pentafluoroacetophenone is a chemical compound with the molecular formula C8H3F5O. It is a white crystalline solid that is commonly used as a building block in organic synthesis. It is used as a reagent in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. The presence of five fluorine atoms on the phenyl ring provides unique reactivity and makes it a valuable intermediate in the production of fluorinated compounds. Additionally, it has applications in the field of materials science and as a reagent in organic chemical reactions. Due to its reactivity and versatility, 2,2,2,3',5'-Pentafluoroacetophenone is an important compound in the field of organic chemistry and chemical research.

Upstream product

• 201230-82-2 carbon monoxide 
• 2265-91-0 1,3-difluoro-5-iodobenzene 
• 340-07-8 N-(trifluoroacetyl)piperidine 
• 461-96-1 3,5-difluorobromobenzene 

Downstream Products

• 1104077-72-6 (E)-3-(3,5-difluorophenyl)-4,4,4-trifluorobut-2-enoic acid 

Relevant articles and documents

Palladium-catalyzed carbonylative coupling of aryl iodides with an organocopper reagent: A straightforward procedure for the synthesis of aryl trifluoromethyl ketones

A palladium-catalyzed carbonylative coupling of aryl iodides with a (trifluoromethyl)copper reagent has been developed. A wide range of substrates have been transformed into their corresponding trifluoromethyl ketones in good to excellent yields under mild conditions with high efficiency and excellent functional-group compatibility. Preliminary mechanistic investigations suggest that the transmetallation of an acylpalladium intermediate with the (trifluoromethyl)copper reagent seems to be involved in the catalytic cycle. Notably, this report represents one of the few studies on carbonylative coupling with organocopper reagents.