845823-12-3

Usage

Uses

Used in Organic Synthesis:
2,2,2,3',5'-Pentafluoroacetophenone is utilized as a building block in organic synthesis for the creation of various pharmaceuticals, agrochemicals, and other organic compounds. Its unique reactivity, stemming from the fluorine atoms on the phenyl ring, makes it a key intermediate in the production of fluorinated compounds.
Used in Materials Science:
In the field of materials science, 2,2,2,3',5'-Pentafluoroacetophenone is employed for its potential applications in developing new materials with enhanced properties, leveraging its reactivity and the characteristics imparted by the fluorine substitution.
Used as a Reagent in Organic Chemical Reactions:
2,2,2,3',5'-Pentafluoroacetophenone serves as a reagent in a range of organic chemical reactions, facilitating the synthesis of complex organic molecules and contributing to the advancement of chemical research and development. Its role in these reactions is crucial for achieving specific transformations and the formation of desired products.

Upstream product

• 340-07-8 N-(trifluoroacetyl)piperidine 
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• 201230-82-2 carbon monoxide 
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Downstream Products

• 945978-37-0 1-(3,4-difluorophenyl)-2,2,2-trifluoroethanol 
• 1104077-72-6 (E)-3-(3,5-difluorophenyl)-4,4,4-trifluorobut-2-enoic acid 
• 1197201-94-7 (Z)-4-(1-(3,5-difluorophenyl)-2,2,2-trifluoroethylidene)-2-phenyloxazol-5(4H)-one 
• 1617507-22-8 (S)-12-(3,5-difluorophenyl)-12-trifluoromethyl-5,6,11,12-tetrahydrobenzo[2,3]azepino[5,6-b]indole 

Relevant academic research and scientific papers

Palladium-catalyzed carbonylative coupling of aryl iodides with an organocopper reagent: A straightforward procedure for the synthesis of aryl trifluoromethyl ketones

A palladium-catalyzed carbonylative coupling of aryl iodides with a (trifluoromethyl)copper reagent has been developed. A wide range of substrates have been transformed into their corresponding trifluoromethyl ketones in good to excellent yields under mild conditions with high efficiency and excellent functional-group compatibility. Preliminary mechanistic investigations suggest that the transmetallation of an acylpalladium intermediate with the (trifluoromethyl)copper reagent seems to be involved in the catalytic cycle. Notably, this report represents one of the few studies on carbonylative coupling with organocopper reagents.

Catalytic asymmetric hydrogenation of α-CF3- or β-CF3-Substituted acrylic acids using Rhodium(I) complexes with a combination of chiral and achiral ligands

Only the mixture works! Acrylic acid derivatives with CF3 substituents in α or β position were efficiently hydrogenated in the presence of a RhI complex with a chiral secondary phosphine oxide (SPO; see scheme) and an achiral Ph3P as ligands. The corresponding propanoic acid derivatives were obtained with generally high conversion (>99 %) and high enantioselectivity (92->99 %). Copyright