360-95-2

Usage

Uses

Used in Pharmaceutical Industry:
4-(Trifluoroacetyl)morpholine is used as a building block for the preparation of various pharmaceuticals. Its unique structure allows for the creation of complex molecules that can be used in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical industry, 4-(Trifluoroacetyl)morpholine serves as a key component in the synthesis of various agrochemicals. Its properties contribute to the effectiveness of these products in agricultural applications.
Used as a Reagent in Organic Synthesis:
4-(Trifluoroacetyl)morpholine is used as a reagent in the production of complex molecules. Its presence in reactions can facilitate the formation of desired products, making it a valuable tool in organic synthesis.
Used as a Solvent in Chemical Reactions:
4-(Trifluoroacetyl)morpholine also functions as a solvent in various chemical reactions. Its ability to dissolve a wide range of substances makes it suitable for use in different reaction conditions.
Used in Medicinal Chemistry Research:
4-(Trifluoroacetyl)morpholine has been studied for its potential use in the field of medicinal chemistry as a possible pharmacophore. Its unique structure may contribute to the development of novel drugs with improved therapeutic properties.

InChI:InChI=1/C6H8F3NO2/c7-6(8,9)5(11)10-1-3-12-4-2-10/h1-4H2

Upstream product

• 110-91-8 morpholine 
• 383-63-1 ethyl trifluoroacetate, 
• 407-25-0 trifluoroacetic anhydride 
• 149229-27-6 2-bromo-2,2-difluoro-1-morpholine-1-yl-ethanone 
• 354-58-5 1,1,1-Trichloro-2,2,2-trifluoroethane 
• 354-38-1 2,2,2-trifluoroacetamide 

Downstream Products

• 123007-81-8 4-((Z)-4-Phenyl-1-trifluoromethyl-but-1-enyl)-morpholine 
• 122982-75-6 4-((E)-4-Phenyl-1-trifluoromethyl-but-1-enyl)-morpholine 
• 186001-41-2 4-((E)-4-Phenyl-1-trifluoromethyl-but-1-enyl)-morpholine 
• 122982-74-5 4-((E)-2-Phenyl-1-trifluoromethyl-vinyl)-morpholine 
• 123007-80-7 (Z)-4-(3,3,3-trifluoro-1-phenylprop-1-en-2-yl)morpholine 
• 122982-74-5 4-((E)-2-Phenyl-1-trifluoromethyl-vinyl)-morpholine 
• 192525-02-3 4-{(E)-2-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-2-heptyloxy-phenyl]-1-trifluoromethyl-vinyl}-morpholine 
• 379-18-0 1,1-diphenyl-2,2,2-trifluoroethanol 
• 1104077-72-6 (E)-3-(3,5-difluorophenyl)-4,4,4-trifluorobut-2-enoic acid 
• 1321562-47-3 1-(4-amino-3,5-dichlorophenyl)-2,2,2-trifluoroethanone 
• 886364-57-4 1-(6-bromopyridin-2-yl)-2,2,2-trifluoroethan-1-one 
• 886364-47-2 1-(6-bromopyridin-3-yl)-2,2,2-trifluoroethan-1-one 
• 130336-16-2 3,5-dichloro-2,2,2-trifluoroacetophenone 
• 400-31-7 1,1,1-trifluoro-4-methyl-pent-3-en-2-one 

Relevant academic research and scientific papers

Catalyst-Free Synthesis of Chromane-Type N,O-Acetals via Intramolecular Addition of Phenols to Enamines

A new strategy to 2-aminochromanes through catalyst-free cascade reaction of 3-trifluoroacetyl-4 H -chromenes and 4 H -chromene-3-carbaldehydes with cyclic secondary amines is presented. The reaction proceeds through subsequent 1,4- and 1,2-additions of amine, bimolecular elimination of trifluoroacetamide or formamide, and 6- exo-trig cyclization. The latter stage is a very rare example of addition of phenols to enamines. The obtained semicyclic N,O-acetals were applied as useful precursors for the synthesis of other chromanes.

A CO2-Catalyzed Transamidation Reaction

Transamidation reactions are often mediated by reactive substrates in the presence of overstoichiometric activating reagents and/or transition metal catalysts. Here we report the use of CO2as a traceless catalyst: in the presence of catalytic amounts of CO2, transamidation reactions were accelerated with primary, secondary, and tertiary amide donors. Various amine nucleophiles including amino acid derivatives were tolerated, showcasing the utility of transamidation in peptide modification and polymer degradation (e.g., Nylon-6,6). In particular,N,O-dimethylhydroxyl amides (Weinreb amides) displayed a distinct reactivity in the CO2-catalyzed transamidation versus a N2atmosphere. Comparative Hammett studies and kinetic analysis were conducted to elucidate the catalytic activation mechanism of molecular CO2, which was supported by DFT calculations. We attributed the positive effect of CO2in the transamidation reaction to the stabilization of tetrahedral intermediates by covalent binding to the electrophilic CO2

Electrochemical approach to trifluoroacetamide synthesis from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) catalyzed by B12complex

One-pot synthetic approach to produce trifluoroacetamide has been developed using an electrochemical method with the B12 complex as a catalyst under mild conditions, in open air at room temperature. Thirty examples of trifluoroacetamide were synthesized from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) in moderate to good yields. This user-friendly strategy is compatible with a broad range of trifluoroacetamide syntheses.

Synthesis of trifluoromethyl moieties by late-stage copper (I) mediated nucleophilic fluorination

The nucleophilic fluorination of bromodifluoromethyl derivatives mediated by the complex (PPh3)3CuF is described. Under the reaction conditions, different trifluoroacetates, trifluoroketones, trifluoroarenes and trifluoroacetamides were obtained in good yields.

Efficient DBU accelerated synthesis of 18F-labelled trifluoroacetamides

Nucleophilic 18F-fluorination of bromodifluoromethyl derivatives was performed using [18F]Bu4NF in the presence of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene). This novel procedure provided a diverse set of [18F]trifluoroacetamides in good to excellent radiochemical conversions. A mechanism where DBU acts as organomediator in this transformation is proposed.

IMIDAZO-, PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES AND THEIR USE

The invention relates to substituted imidazo-, pyrazolopyrazines and imidazotriazines and processes for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of hematological di

SUBSTITUTED IMIDAZO- AND TRIAZOLOPYRIMIDINES, IMIDAZO- AND PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES

The invention relates to substituted imidazo- and triazolopyrimidines, imidazo- and pyrazolopyrazines and imidazotriazines and processes for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of hematological disorders, preferably of leukopenias and neutropenias.

SUBSTITUTED PYRIDINES, AND USE THEREOF AS GSK3 INHIBITORS

The invention relates to substituted pyridines and to processes for preparation thereof, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of haematological disorders, preferably of leukopenia and neutropenia

SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES

The invention relates to substituted imidazopyrimidines and triazolopyrimidines, to methods for the production thereof, and to the use of same for producing medicaments for the treatment and/or prophylaxis of diseases, especially haematological diseases, preferably leucopenia and neutropenia.

PROCESS FOR THE PREPARATION OF TRIFLUOROALKYL-PHENYL AND HETEROCYCLIC SULFONAMIDES

A novel trifluoroacetylating agent, i.e., N-trifluoroacetylmorpholine, is described. This reagent is useful in the preparation of phenyl and heterocyclic sulfonamide compounds. Methods are therefore described for preparing sulfonamide compounds of the fol