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1104443-04-0

tert-butyl 3-(((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yl)oxy)methyl)pyrrolidine-1-carboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1104443-04-0 Structure

  • Basic information

    1. Product Name: tert-butyl 3-(((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yl)oxy)methyl)pyrrolidine-1-carboxylate
    2. Synonyms: tert-butyl 3-(((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yl)oxy)methyl)pyrrolidine-1-carboxylate
    3. CAS NO:1104443-04-0
    4. Molecular Formula:
    5. Molecular Weight: 448.54
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1104443-04-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: tert-butyl 3-(((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yl)oxy)methyl)pyrrolidine-1-carboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: tert-butyl 3-(((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yl)oxy)methyl)pyrrolidine-1-carboxylate(1104443-04-0)
    11. EPA Substance Registry System: tert-butyl 3-(((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yl)oxy)methyl)pyrrolidine-1-carboxylate(1104443-04-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1104443-04-0(Hazardous Substances Data)

1104443-04-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1104443-04-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,0,4,4,4 and 3 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1104443-04:
(9*1)+(8*1)+(7*0)+(6*4)+(5*4)+(4*4)+(3*3)+(2*0)+(1*4)=90
90 % 10 = 0
So 1104443-04-0 is a valid CAS Registry Number.

1104443-04-0Downstream Products

1104443-04-0Relevant articles and documents

Discovery of 5-chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1 H)-one (BMS-903452), an antidiabetic clinical candidate targeting GPR119

Wacker, Dean A.,Wang, Ying,Broekema, Matthias,Rossi, Karen,Oconnor, Steven,Hong, Zhenqiu,Wu, Ginger,Malmstrom, Sarah E.,Hung, Chen-Pin,Lamarre, Linda,Chimalakonda, Anjaneya,Zhang, Lisa,Xin, Li,Cai, Hong,Chu, Cuixia,Boehm, Stephanie,Zalaznick, Jacob,Ponticiello, Randolph,Sereda, Larisa,Han, Song-Ping,Zebo, Rachel,Zinker, Bradley,Luk, Chiuwa Emily,Wong, Richard,Everlof, Gerry,Li, Yi-Xin,Wu, Chunyu K.,Lee, Michelle,Griffen, Steven,Miller, Keith J.,Krupinski, John,Robl, Jeffrey A.

, p. 7499 - 7508 (2014/12/11)

G-protein-coupled receptor 119 (GPR119) is expressed predominantly in pancreatic β-cells and in enteroendocrine cells in the gastrointestinal tract. GPR119 agonists have been shown to stimulate glucose-dependent insulin release by direct action in the pancreas and to promote secretion of the incretin GLP-1 by action in the gastrointestinal tract. This dual mechanism of action has generated significant interest in the discovery of small molecule GPR119 agonists as a potential new treatment for type 2 diabetes. Herein, we describe the discovery and optimization of a new class of pyridone containing GPR119 agonists. The potent and selective BMS-903452 (42) was efficacious in both acute and chronic in vivo rodent models of diabetes. Dosing of 42 in a single ascending dose study in normal healthy humans showed a dose dependent increase in exposure and a trend toward increased total GLP-1 plasma levels.

PYRIDONE GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS

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Page/Page column 62-63, (2009/02/11)

Novel compounds are provided which are GPR119 G protein-coupled receptor modulators. GPR119 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring GPR 119 G protein-coupled receptor modulator therapy. These novel compounds have the structure Formula I or Formula IA.

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