110454-40-5Relevant academic research and scientific papers
1,3-SYN DIASTEREOSELECTIVE REDUCTION OF β-HYDROXYKETONES UTILIZING ALKOXYDIALKYLBORANES
Chen, Kau-Ming,Hardtmann, Goetz E.,Prasad, Kapa,Repic, Oljan,Shapiro, Michael J.
, p. 155 - 158 (1987)
Sodium borohydride reduction of β-hydroxyketones in presence of alkoxydialkylboranes 1-7 as complexing agents, produced 1,3-syn diols in at least 98:2 ratio.As illustrated with examples 8-17 this method is quite general and superior to those described in
A PROCESS FOR SYNTHESIS OF LARGE PARTICLE SIZE STATIN COMPOUNDS.
-
Page/Page column 22, (2008/06/13)
This invention discloses a process for synthesis of with large size statin compounds comprising adding solution of desired statin compound either crystalline or amorphous form, optionally obtained from, their intermediates by known methods, in organic solvent to anti-solvent, under stirring, optionally the solvent was being evaporated, isolating the title compound by centrifugation followed by drying under vacuum. Specifically the process was directed to the synthesis of Atorvastatin calcium and Fluvastatin Sodium.
