1104599-57-6

Basic information

• Product Name: (1R,3R)-3-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
• Synonyms: (1R,3R)-3-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
• CAS NO: 1104599-57-6
• Molecular Weight: 412.469
• Mol File: 1104599-57-6.mol

Chemical Properties

• CAS DataBase Reference: (1R,3R)-3-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,3R)-3-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole(1104599-57-6)
• EPA Substance Registry System: (1R,3R)-3-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole(1104599-57-6)

Safety Data

• Hazardous Substances Data: 1104599-57-6(Hazardous Substances Data)

Upstream product

• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 5241-64-5 Boc-D-Trp-OH 
• 1104606-06-5 (R)-tert-butyl (1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-2-(1H-indol-3-yl)ethyl)carbamate 
• 25016-11-9 1-methylpyrazole-4-carbaldehyde 
• 1104606-50-9 (R)-1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-2-(1H-indol-3-yl)-ethanamine hydrochloride 

Relevant articles and documents

The discovery of MK-4256, a potent SSTR3 antagonist as a potential treatment of type 2 diabetes

A structure-activity relationship study of the imidazolyl-β- tetrahydrocarboline series identified MK-4256 as a potent, selective SSTR3 antagonist, which demonstrated superior efficacy in a mouse oGTT model. MK-4256 reduced glucose excursion in a dose-dependent fashion with maximal efficacy achieved at doses as low as 0.03 mg/kg po. As compared with glipizide, MK-4256 showed a minimal hypoglycemia risk in mice.