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1104606-06-5

(R)-tert-butyl (1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-2-(1H-indol-3-yl)ethyl)carbamate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1104606-06-5 Structure

  • Basic information

    1. Product Name: (R)-tert-butyl (1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-2-(1H-indol-3-yl)ethyl)carbamate
    2. Synonyms: (R)-tert-butyl (1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-2-(1H-indol-3-yl)ethyl)carbamate
    3. CAS NO:1104606-06-5
    4. Molecular Formula:
    5. Molecular Weight: 420.487
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1104606-06-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (R)-tert-butyl (1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-2-(1H-indol-3-yl)ethyl)carbamate(CAS DataBase Reference)
    10. NIST Chemistry Reference: (R)-tert-butyl (1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-2-(1H-indol-3-yl)ethyl)carbamate(1104606-06-5)
    11. EPA Substance Registry System: (R)-tert-butyl (1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-2-(1H-indol-3-yl)ethyl)carbamate(1104606-06-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1104606-06-5(Hazardous Substances Data)

1104606-06-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1104606-06-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,0,4,6,0 and 6 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1104606-06:
(9*1)+(8*1)+(7*0)+(6*4)+(5*6)+(4*0)+(3*6)+(2*0)+(1*6)=95
95 % 10 = 5
So 1104606-06-5 is a valid CAS Registry Number.

1104606-06-5Downstream Products

1104606-06-5Relevant articles and documents

SAR exploration at the C-3 position of tetrahydro-β-carboline sstr3 antagonists

He, Shuwen,Dobbelaar, Peter H.,Guo, Liangqin,Ye, Zhixiong,Liu, Jian,Jian, Tianying,Truong, Quang,Shah, Shrenik K.,Du, Wu,Qi, Hongbo,Bakshi, Raman K.,Hong, Qingmei,Dellureficio, James D.,Sherer, Edward,Pasternak, Alexander,Feng, Zhe,Reibarkh, Mikhail,Lin, Melissa,Samuel, Koppara,Reddy, Vijay B.,Mitelman, Stan,Tong, Sharon X.,Chicchi, Gary G.,Tsao, Kwei-Lan,Trusca, Dorina,Wu, Margaret,Shao, Qing,Trujillo, Maria E.,Fernandez, Guillermo,Nelson, Donald,Bunting, Patricia,Kerr, Janet,Fitzgerald, Patrick,Morissette, Pierre,Volksdorf, Sylvia,Eiermann, George J.,Li, Cai,Zhang, Bei B.,Howard, Andrew D.,Zhou, Yun-Ping,Nargund, Ravi P.,Hagmann, William K.

, p. 1529 - 1535 (2016/07/27)

MK-4256, a tetrahydro-β-carboline sstr3 antagonist, was discontinued due to a cardiovascular (CV) adverse effect observed in dogs. Additional investigations revealed that the CV liability (QTc prolongation) was caused by the hERG off-target activity of MK-4256 and was not due to sstr3 antagonism. In this Letter, we describe our extensive SAR effort at the C3 position of the tetrahydro-β-carboline structure. This effort resulted in identification of 5-fluoro-pyridin-2-yl as the optimal substituent on the imidazole ring to balance sstr3 activity and the hERG off-target liability.

Route development and multikilogram GMP delivery of a somatostatin receptor antagonist

Ruck, Rebecca T.,Huffman, Mark A.,Stewart, Gavin W.,Cleator, Ed,Kandur, Wynne V.,Kim, Mary M.,Zhao, Dalian

, p. 1329 - 1337 (2012/10/29)

Route development and demonstration on multikilogram scale for the first GMP delivery of MK-4256 are described. Key aspects of the convergent route include a regioselective green iodination, one-pot oxadiazole synthesis, and an efficient ketone Pictet-Spengler reaction with diastereomeric upgrade via crystallization to afford 6 kg of API. A recycle procedure augmented the yield of desired diastereomer in the Pictet-Spengler reaction from a mixture of diastereomers heavily enriched in the undesired diastereomer.

The discovery of MK-4256, a potent SSTR3 antagonist as a potential treatment of type 2 diabetes

He, Shuwen,Ye, Zhixiong,Truong, Quang,Shah, Shrenik,Du, Wu,Guo, Liangqin,Dobbelaar, Peter H.,Lai, Zhong,Liu, Jian,Jian, Tianying,Qi, Hongbo,Bakshi, Raman K.,Hong, Qingmei,Dellureficio, James,Pasternak, Alexander,Feng, Zhe,Dejesus, Reynalda,Yang, Lihu,Reibarkh, Mikhail,Bradley, Scott A.,Holmes, Mark A.,Ball, Richard G.,Ruck, Rebecca T.,Huffman, Mark A.,Wong, Frederick,Samuel, Koppara,Reddy, Vijay B.,Mitelman, Stan,Tong, Sharon X.,Chicchi, Gary G.,Tsao, Kwei-Lan,Trusca, Dorina,Wu, Margaret,Shao, Qing,Trujillo, Maria E.,Eiermann, George J.,Li, Cai,Zhang, Bei B.,Howard, Andrew D.,Zhou, Yun-Ping,Nargund, Ravi P.,Hagmann, William K.

supporting information; experimental part, p. 484 - 489 (2012/10/08)

A structure-activity relationship study of the imidazolyl-β- tetrahydrocarboline series identified MK-4256 as a potent, selective SSTR3 antagonist, which demonstrated superior efficacy in a mouse oGTT model. MK-4256 reduced glucose excursion in a dose-dependent fashion with maximal efficacy achieved at doses as low as 0.03 mg/kg po. As compared with glipizide, MK-4256 showed a minimal hypoglycemia risk in mice.

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