11046-16-5

Basic information

• Product Name: 1,2,5-trimethyl-2,3,4,6-tetrahydro-1H-pyrido[4,3-b]carbazole
• CAS NO: 11046-16-5
• Molecular Formula: C₁₈H₂₀N₂
• Molecular Weight: 264.3648
• Mol File: 11046-16-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 448°C at 760 mmHg
• Flash Point: 224.7°C
• Density: 1.148g/cm³
• Vapor Pressure: 3.21E-08mmHg at 25°C
• Refractive Index: 1.673
• CAS DataBase Reference: 1,2,5-trimethyl-2,3,4,6-tetrahydro-1H-pyrido[4,3-b]carbazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,5-trimethyl-2,3,4,6-tetrahydro-1H-pyrido[4,3-b]carbazole(11046-16-5)
• EPA Substance Registry System: 1,2,5-trimethyl-2,3,4,6-tetrahydro-1H-pyrido[4,3-b]carbazole(11046-16-5)

Safety Data

• Hazardous Substances Data: 11046-16-5(Hazardous Substances Data)

Usage

Structure

Polycyclic aromatic hydrocarbon with a pyrido[4,3-b]carbazole core

Usage

Mainly used in scientific research

Availability

Not widely commercially available

Pharmacological properties

Studied for potential properties

Biological processes

Investigated for role in various processes

Potential applications

Studied as an anti-cancer agent

Research status

More research needed to fully understand properties and applications

Upstream product

• 67-56-1 methanol 
• 98494-80-5 1,2,5-trimethyl-6H-pyrido[4,3-b]carbazolium; iodide 
• 64-17-5 ethanol 
• 40899-89-6 1-(1-benzenesulfonyl indole-2-yl)-1-(4-pyridyl)-ethanol 
• 40899-71-6 1-benzenesulfonylindole 
• 120-72-9 indole 
• 4238-66-8 11-demethylellipticine 
• 79820-57-8 indole-2-yl-1-(4-pyridyl)-ethanol 
• 79820-58-9 indole-2-yl-1-(4-pyridylmethiodide)-ethanol 
• 878003-42-0 Se-phenyl 3-((1,2-dimethyl-1,2,5,6-tetrahydro-3-pyridyl)methyl)-1H-2-indolecarboselenoate 
• 878003-43-1 1,2-dimethyl-1,2,3,4,4a,6,11,11a-octahydro-pyrido[4,3-b]carbazol-5-one 
• 484-49-1 Guatambuinine 
• 74-88-4 methyl iodide 

Downstream Products

• 484-49-1 Guatambuinine 

Relevant articles and documents

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Synthesis and cytotoxicity of pyrido[4,3-b]carbazole alkaloids against HCT-116 and HL-60 cells

Ellipticine, olivacine, and their five reduced natural variants were synthesized via a palladium-catalyzed tandem cyclization/cross-coupling reaction as the key step. In addition, a previously unknown conformer of janetine was obtained through conformational inversion of the D ring in janetine. Because there are few synthetic approaches for reduced natural variants, little is known about the biological activities of these compounds. Six synthetic natural alkaloids and five of their derivatives were evaluated for their antiproliferative activity against HCT-116 and HL-60 cells. The activities of variants with the D-reduced ring or without the C(11)-Me group were lower than those of ellipticine. The conformer of guatambuine showed higher activities than guatambuine.

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Regioselective 6-endo cyclizations of 2-indolylacyl radicals: Total synthesis of the pyrido[4,3-b]carbazole alkaloid guatambuine

A regioselective 6-endo reductive cyclization of 2-indolylacyl radicals constitutes the key step of a straightforward synthetic entry to the olivacine skeleton, illustrated by a total synthesis of the tetrahydropyridine alkaloid guatambuine.