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1104604-48-9

(1S,3R)-3-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1104604-48-9 Structure

  • Basic information

    1. Product Name: (1S,3R)-3-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
    2. Synonyms: (1S,3R)-3-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
    3. CAS NO:1104604-48-9
    4. Molecular Formula:
    5. Molecular Weight: 412.469
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1104604-48-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (1S,3R)-3-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole(CAS DataBase Reference)
    10. NIST Chemistry Reference: (1S,3R)-3-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole(1104604-48-9)
    11. EPA Substance Registry System: (1S,3R)-3-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole(1104604-48-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1104604-48-9(Hazardous Substances Data)

1104604-48-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1104604-48-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,0,4,6,0 and 4 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1104604-48:
(9*1)+(8*1)+(7*0)+(6*4)+(5*6)+(4*0)+(3*4)+(2*4)+(1*8)=99
99 % 10 = 9
So 1104604-48-9 is a valid CAS Registry Number.

1104604-48-9Downstream Products

1104604-48-9Relevant articles and documents

The discovery of MK-4256, a potent SSTR3 antagonist as a potential treatment of type 2 diabetes

He, Shuwen,Ye, Zhixiong,Truong, Quang,Shah, Shrenik,Du, Wu,Guo, Liangqin,Dobbelaar, Peter H.,Lai, Zhong,Liu, Jian,Jian, Tianying,Qi, Hongbo,Bakshi, Raman K.,Hong, Qingmei,Dellureficio, James,Pasternak, Alexander,Feng, Zhe,Dejesus, Reynalda,Yang, Lihu,Reibarkh, Mikhail,Bradley, Scott A.,Holmes, Mark A.,Ball, Richard G.,Ruck, Rebecca T.,Huffman, Mark A.,Wong, Frederick,Samuel, Koppara,Reddy, Vijay B.,Mitelman, Stan,Tong, Sharon X.,Chicchi, Gary G.,Tsao, Kwei-Lan,Trusca, Dorina,Wu, Margaret,Shao, Qing,Trujillo, Maria E.,Eiermann, George J.,Li, Cai,Zhang, Bei B.,Howard, Andrew D.,Zhou, Yun-Ping,Nargund, Ravi P.,Hagmann, William K.

, p. 484 - 489 (2012/10/08)

A structure-activity relationship study of the imidazolyl-β- tetrahydrocarboline series identified MK-4256 as a potent, selective SSTR3 antagonist, which demonstrated superior efficacy in a mouse oGTT model. MK-4256 reduced glucose excursion in a dose-dependent fashion with maximal efficacy achieved at doses as low as 0.03 mg/kg po. As compared with glipizide, MK-4256 showed a minimal hypoglycemia risk in mice.

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