110490-58-9Relevant articles and documents
Synthesis, biological evaluation and in silico studies of tetrazole-heterocycle hybrids
Sribalan, Rajendran,Banuppriya, Govindharasu,Kirubavathi, Maruthan,Padmini, Vediappen
, p. 577 - 586 (2018/09/14)
The series of three different chemical entities of tetrazole-heterocycle hybrids such as thiophene, pyridine and quinoline tetrazoles were synthesized and characterized for the purpose to develop new lead molecules. Biological evaluations such as in vitro antimicrobial and anti-inflammatory activities were studied. Further, the in silico studies such as Molecular docking (with COX-1, COX-2 and 3TTZ), DFT calculations, the Molecular electrostatic potential (MEP) and ADME were investigated.
Synthesis method of quinoline amide compounds
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Paragraph 0036; 0037; 0038; 0039; 0040, (2016/12/01)
The invention relates to a synthesis method of quinoline amide compounds shown in the formula (III). The method comprises steps as follows: a compound shown in the formula (I) and a compound shown in the formula (II) have a reaction in an organic solvent
Copper-catalyzed efficient direct amidation of 2-methylquinolines with amines
Xie, Hao,Liao, Yunfeng,Chen, Shuqing,Chen, Ya,Deng, Guo-Jun
supporting information, p. 6944 - 6948 (2015/06/30)
A novel Cu-catalyzed direct amidation of 2-methylquinolines with amines is described. This method afforded an efficient approach for the synthesis of biologically important aromatic amides from readily available coupling partners using molecular oxygen as the oxidant.
