110490-58-9Relevant academic research and scientific papers
Synthesis, biological evaluation and in silico studies of tetrazole-heterocycle hybrids
Sribalan, Rajendran,Banuppriya, Govindharasu,Kirubavathi, Maruthan,Padmini, Vediappen
, p. 577 - 586 (2018/09/14)
The series of three different chemical entities of tetrazole-heterocycle hybrids such as thiophene, pyridine and quinoline tetrazoles were synthesized and characterized for the purpose to develop new lead molecules. Biological evaluations such as in vitro antimicrobial and anti-inflammatory activities were studied. Further, the in silico studies such as Molecular docking (with COX-1, COX-2 and 3TTZ), DFT calculations, the Molecular electrostatic potential (MEP) and ADME were investigated.
A two-stage, three-stage aromatic amide compound synthesis method
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Paragraph 0029-0031, (2017/10/06)
The invention provides a synthetic method for forming binary and ternary aryl amide compounds by virtue of direct methyl functionalization. The method comprises the following steps: by taking a 2-methyl-N-heterocyclic aromatic hydrocarbon and an amine sou
Synthesis method of quinoline amide compounds
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Paragraph 0036; 0037; 0038; 0039; 0040, (2016/12/01)
The invention relates to a synthesis method of quinoline amide compounds shown in the formula (III). The method comprises steps as follows: a compound shown in the formula (I) and a compound shown in the formula (II) have a reaction in an organic solvent
Copper catalysed direct amidation of methyl groups with N-H bonds
Huang, Yao,Chen, Tieqiao,Li, Qiang,Zhou, Yongbo,Yin, Shuang-Feng
, p. 7289 - 7293 (2015/07/01)
An efficient copper catalyzed direct aerobic oxidative amidation of methyl groups of azaarylmethanes with N-H bonds producing amides is successfully developed, which can produce primary, secondary and tertiary amides, including those with functional groups. This reaction represents a straightforward method for the preparation of amides from the readily available hydrocarbon starting materials.
Copper-catalyzed efficient direct amidation of 2-methylquinolines with amines
Xie, Hao,Liao, Yunfeng,Chen, Shuqing,Chen, Ya,Deng, Guo-Jun
supporting information, p. 6944 - 6948 (2015/06/30)
A novel Cu-catalyzed direct amidation of 2-methylquinolines with amines is described. This method afforded an efficient approach for the synthesis of biologically important aromatic amides from readily available coupling partners using molecular oxygen as the oxidant.
