1104997-33-2

Upstream product

• 91-01-0 1,1-Diphenylmethanol 
• 76711-42-7 (E)-2-(4-methoxyphenyl)-1-trimethylsilylethene 
• 1147765-35-2 1,3-bis((E)-4-methoxystyryl)-1,1,3,3-tetramethyldisiloxane 
• 90-99-3 diphenylchloromethane 
• 3262-89-3 triphenylboroxine 

Relevant academic research and scientific papers

Enantiospecific, nickel-catalyzed cross-couplings of allylic pivalates and arylboroxines

We have developed an enantiospecific, nickel-catalyzed cross-coupling of unsymmetric 1,3-disubstituted allylic pivalates with arylboroxines. The success of this reaction relies on the use of BnPPh2 as a supporting ligand for the nickel(0) catalyst and NaOMe as a base. This method shows excellent functional group tolerance and broad scope in both the allylic pivalate and arylboroxine, enabling the preparation of 1,3-diaryl allylic products in high yields with excellent levels of regioselectivity and stereochemical fidelity.

Palladium-catalysed cross-coupling of vinyldisiloxanes with benzylic and allylic halides and sulfonates

The Hiyama cross-coupling reaction is a powerful method for carbon-carbon bond formation. To date, the substrate scope of this reaction has predominantly been limited to sp2-sp2 coupling reactions. Herein, the palladium-catalysed Hiyama type cross-coupling of vinyldisiloxanes with benzylic and allylic bromides, chlorides, tosylates and mesylates is reported. A wide variety of functional groups were tolerated, and the synthetic utility of the methodology was exemplified through the efficient total synthesis of the cytotoxic natural product bussealin A. In addition, the antiproliferative ability of bussealin A was evaluated in two cancer-cell lines. Copyright

Direct coupling of alcohols with alkenylsilanes catalyzed by indium trichloride or bismuth tribromide

Indium halides or bismuth halides catalyzed the coupling of various alcohols with alkenylsilanes to give the corresponding alkenes stereospecifically without any other activators. The Royal Society of Chemistry 2008.