110582-08-6Relevant academic research and scientific papers
Zinc-Chloride-Promoted Domino Reaction of Phenols with Terminal Alkynes under Solvent-Free Conditions: An Efficient Synthesis of Chromenes
Sreenivasulu, Chinnabattigalla,Satyanarayana, Gedu
, p. 2846 - 2857 (2018)
A domino one-pot synthesis of 2H-chromenes and 4H-chromenes starting from phenols and terminal acetylenes in an atom economical reaction under solvent-free conditions is described. This annulation reaction between phenols with alkynes is promoted by the simple Lewis acid ZnCl2. Significantly, to the best of our knowledge, the synthesis of 2H-chromenes is the first of its kind, as it is based on the use of terminal alkyl acetylenes. The described method shows a broad substrate scope and good functional group tolerance.
A simple Lewis acid induced reaction of phenols with electrophiles: Synthesis of functionalized 4H-chromenes and ortho-benzylphenols
Sreenivasulu, Chinnabattigalla,Thadathil, Ditto Abraham,Pal, Sumit,Gedu, Satyanarayana
, p. 112 - 122 (2019/11/19)
Lewis acid ZnCl2 promoted cyclization protocol to 4H-chromenes is accomplished, using readily available phenols and acetophenones as starting materials. Interestingly, the process is feasible under the solvent free environment. Synthesis of a variety of 4H-chromenes have been accomplished using this strategy. In addition, this concept is extended to the synthesis of ortho-benzylphenols by treating phenols either with styrenes or secondary benzylic alcohols.
Gold(III)-catalyzed tandem reaction of ketones with phenols: Efficient and highly selective synthesis of functionalized 4H-chromenes
Liu, Yunkui,Qian, Jianqiang,Lou, Shaojie,Zhu, Jie,Xu, Zhenyuan
supporting information; experimental part, p. 1309 - 1312 (2010/04/26)
(Chemical Equation Presented) An efficient and highly selective approach for the synthesis of functionalized 4H-chromenes has been developed via gold(III)-catalyzed condensation/annulation tandem reaction of ketones with phenols.
REACTION OF PHENOL WITH ACETOPHENONE IN THE PRESENCE OF ALUMINUM PHENOLATE
Kozlikovskii, Ya. B.,Chernyaev, B. V.,Litvin, A. L.
, p. 2146 - 2149 (2007/10/02)
The reaction of phenol with acetophenone in the presence of aluminum phenolate leads to a mixture of the respective 1,1-diarylethene, 1,1,1-triarylethanes, substituted chromenes and chromanes, and the dimer and trimer of the initial ketone.
