110646-16-7

Upstream product

• 626-34-6 ethyl aminocrotonate 
• 99-61-6 3-nitro-benzaldehyde 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 156-57-0 2-mercaptoethylamine hydrochloride 
• 105435-14-1 2-chloromethyl-3,5-dicarboethoxy-4-(3-nitrophenyl)-6-methyl-1,4-dihydropyridine 

Downstream Products

• 110646-94-1 2-[2-N-(2-cyanoethyl)aminoethylthio]methyl-3,5-dicarboethoxy-4-(m-nitrophenyl)-6-methyl-1,4-dihydropyridine 
• 110646-91-8 2-[(2-acetoxyethyl)thio] methyl-3,5-dicarboethoxy-4-(m-nitrophenyl)-6-methyl-1, 4-dihydropyridine 
• 1026503-75-2 2-Methyl-4-(3-nitro-phenyl)-6-(2-thioureido-ethylsulfanylmethyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 160174-51-6 N-benzoyl-N'-<2-<(3,5-diethoxycarbonyl-1,4-dihydro-6-methyl-4-(3-nitrophenyl)pyridin-2-yl)methylthio>ethyl>thiourea 

Relevant academic research and scientific papers

Synthesis and in vitro pharmacology of new 1,4-dihydropyridines. 1. 2-(ω-Aminoalkylthiomethyl)-1,4-dihydropyridines as potent calcium channel blockers

The synthesis and in vitro calcium channel blocking activities and binding of 2-(ω-aminoalkylthiomethyl)-4-(substituted)phenyl-1,4- dihydropyridines, by determination of the displacement of [3H]nitrendipine from the calcium channel binding sites on rat cortex have been discussed. It has been shown that increasing the alkyl chain length on the 2-position of the 1,4-dihydropyridine ring from ethyl to pentyl does not affect the calcium channel blocking activity of 3-nitrophenyl substituted dihydropyridines, measured on K+-depolarisation induced contractile responses in rat aorta strips. It did not seem to be important whether the 1,4-dihydropyridines bore 2 identical or different ester moieties on the 3- and 5-position of the 1,4-dihydropyridine ring.