110646-22-5Relevant academic research and scientific papers
Metalation of Hantzsch Esters and Mixed Amide Esters: A General Route to C-2 Functionalized 1,4-Dihydropyridines
Poindexter, Graham S.,Licause, Joseph F.,Dolan, Peter L.,Foley, Michael A.,Combs, Charles M.
, p. 3811 - 3820 (2007/10/02)
1,4-Dihydropyridine (Hantzsch) diesters 3a-e readily undergo metalation at the C-2 methyl (vinylogous ester) position on treatment with alkyllithium bases.The resulting anion intermediates can be treated with electrophilic reagents to afford 1,4-dihydropy
METALATION OF 1,4-DIHYDROPYRIDINE ESTERS
Poindexter, Graham S.,Foley, Michael A.,Licause, Joseph F.
, p. 3393 - 3396 (2007/10/02)
4-Aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic esters are metalated at the NH and the C-2 methyl positions via treatment with two equivalents of n-butyl lithium.The resulting dilithio species can be treated with a variety of electrophiles to fur
