110683-64-2

Upstream product

• 1589-82-8 phenylmagnesium bromide 
• 15733-63-8 5-chloropentylbenzene 
• 14469-83-1 (5-bromopentyl)benzene 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 10521-91-2 5-phenylpentan-1-ol 
• 158771-44-9 methyl 4-(5-phenylpentyloxy)benzoate 

Downstream Products

• 885313-13-3 ethyl 4-cyclohexylamino-3-[4-(5-phenylpentoxy)benzoylamino]benzoate 
• 885313-14-4 ethyl 1-cyclohexyl-2-[4-(5-phenylpentyloxy)phenyl]-1H-benzimidazole-5-carboxylate 
• 103176-74-5 4-(5-Phenyl-pentyloxy)-N-[3-(1H-tetrazol-5-yl)-2,3-dihydro-benzo[1,4]dioxin-5-yl]-benzamide 

Relevant academic research and scientific papers

Bent-core mesogens with an aromatic unit at the terminal position

Bent-core liquid crystals with a naphthalene central unit and an aromatic ring at the terminal position of molecular tails were synthesised with the aim of enhancing nanosegregation. It was found that the length of the spacer between the rigid core and the terminal aromatic moiety had a profound influence on the liquid crystal polymorphism. The homologues with short spacers exhibited nematic and columnar phases, whereas the homologue with long spacers exhibited a tilted lamellar phase with a liquid-like in-plane order, indicating an unusual morphology of the densely packed toroidal objects. The morphology can be changed to twisted ribbons by small additives adsorbed on the membrane surface. This is the first example of twisted ribbons constructed by a lamellar system with no long-range in-plane order.

Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: Identification of 2-[(4-diarylmethoxy)phenyl]-benzimidazole

A series of 1-cycloalkyl-2-phenyl-1H-benzimidazole-5-carboxylic acid derivatives was synthesized and evaluated for inhibitory activity against HCV NS5B RNA-dependent RNA polymerase (RdRp). A SAR study was performed and led to identify the 2-[(4-diarylmeth

A novel class of inhibitors for human steroid 5α-reductase: Phenoxybenzoic acid derivatives. I

In a search for novel nonsteroidal inhibitors of human prostatic 5α- reductase, we found anew series of phenoxybenzoic acid derivatives to be potent human prostatic 5α-reductase inhibitors. Among them, 4-(biphenyl-4- yloxy)benzoic acid derivatives (2n, YM

New potent antagonists of leukotrienes C4 and D4. 1. Synthesis and structure-activity relationships

(p-Amylcinnamoyl)anthranilic acid (3a) had moderate antagonist activities against LTD4-induced smooth muscle contraction on guinea pig ileum and LTC4-induced bronchoconstriction in anesthetized guinea pigs. Modifications were made in the hydrophobic part (cinnamoyl moiety) and the hydrophilic part (anthranilate moiety) of 3a. A series of 8-(benzoylamino)-2-tetrazol-5-yl-1,4-benzodioxans and 8-(benzoylamino)-2-tetrazol-5-yl-4-oxo-4H-1-benzopyrans were revealed to be potent antagonists of leukotrienes C4 and D4. Among both series, ONO-RS-347 (18k) and ONO-RS411 (19h) were the most potent and orally active antagonists, respectively. Structure-activity relationships are discussed.