110684-22-5Relevant academic research and scientific papers
COMPOUNDS AS CASEIN KINASE INHIBITORS
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, (2021/10/02)
Provided are novel casein kinase inhibitors, or pharmaceutically acceptable salts thereof. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also provided.
METHODS FOR INHIBITING CASEIN KINASES
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, (2021/10/02)
The present disclosure provides methods for inhibiting CK1 delta or CK1 epsilon activity, comprising administering an effective amount of the compound of Formula (I) to (IV), or a pharmaceutically acceptable salt thereof.
Design and combinatorial synthesis of a novel kinase-focused library using click chemistry-based fragment assembly
Irie, Takayuki,Fujii, Ikuo,Sawa, Masaaki
scheme or table, p. 591 - 596 (2012/03/11)
Fragment-based lead discovery is a new approach for lead generation that has emerged in the past decade. Because the initial fragments identified in the fragment screening typically show weak binding affinity, an intensive medicinal chemistry effort would be required to grow initial fragments into a potential lead compound. Here we demonstrate a kinase focused evolved fragment (KFEF) library, constructed by click chemistry-based fragment assembly, that is a valuable source of kinase inhibitors. This combinatorial assembly of two fragments, kinase-privileged alkyne fragments and diversified azide fragments, by two cycloaddition reactions shows a unique potential for the one-step synthesis of structurally diverse evolved fragments. The screening of this triazole-based KFEF library allowed the rapid identification of potent lead candidates for FLT3 and GSK3β kinase.
Triazolines. 19. Nickel Peroxide Oxidation of Δ2-1,2,3-Triazolines. A Versatile General Synthetic Route to 1H-1,2,3-Triazoles
Kadaba, Pankaja K.,Edelstein, Steven B.
, p. 5891 - 5894 (2007/10/02)
Although the oxidative dehydrogenation of Δ2-1,2,3-triazolines using potassium permanganate in a phase-transfer catalyzed reaction system affords a convenient route for the synthesis of a number of 1-aryl-5-heteroaryl-substituted 1H-1,2,3-triaz
Triazolines. 14. 1,2,3-Triazolines and Triazoles, a New Class of Anticonvulsants. Drug Design and Structure-Activity Relationships
Kadaba, Pankaja
, p. 196 - 203 (2007/10/02)
Pioneering studies in our laboratory have led to the emergence og the Δ2-1,2,3-triazolines (4,5-dihydro-1H-1,2,3-triazoles) and the closely related 1H-1,2,3-triazoles as a unique family of anticonvulsant agents hitherto unknown.Unlike the tradi
