110729-51-6

Basic information

• Product Name: 2-Fluoro-N-Methyl-5-nitroaniline
• Synonyms: 2-Fluoro-N-Methyl-5-nitroaniline
• CAS NO: 110729-51-6
• Molecular Formula: C₇H₇FN₂O₂
• Molecular Weight: 170.1410832
• Mol File: 110729-51-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 270.3±30.0 °C(Predicted)
• Appearance: /
• Density: 1.361±0.06 g/cm3(Predicted)
• PKA: 2.12±0.25(Predicted)
• CAS DataBase Reference: 2-Fluoro-N-Methyl-5-nitroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-N-Methyl-5-nitroaniline(110729-51-6)
• EPA Substance Registry System: 2-Fluoro-N-Methyl-5-nitroaniline(110729-51-6)

Safety Data

• Hazardous Substances Data: 110729-51-6(Hazardous Substances Data)

Usage

Uses

2-Fluoro-N-Methyl-5-nitroaniline can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical and pharmaceutical production process.

Synthesis

2-fluoro-5-nitroaniline (20.0g, 128.2mmol) and paraformaldehyde (16.0g, 533.3mmol) was dissolved in 500mL of methanol then stirred at room temperature. Then added dropwise NaOMe (3.4g, 63mmol) in methanol 100mL. The reaction was stirred at room temperature for 16 hours then was added NaBH4 (9.7g, 255.2mmol) in two aliquots, stirred for 15 minutes. LCMS traced the reaction. After completion of the reaction was poured into 1M KOH aqueous solution, and stirred to precipitate a solid. Filtered to give a yellow solid 2-fluoro-N-methyl-5-nitroaniline (19.0g, 87% yield).

Upstream product

• 50-00-0 formaldehyd 
• 369-36-8 6-fluoro-3-nitroaniline 

Downstream Products

• 449760-94-5 N-methyl-5-nitro-2-[2-(1,2,3,4-tetrahydroisoquinolyl)]aniline 
• 157921-53-4 N-(2-Fluoro-5-nitro-phenyl)-N-methyl-methanesulfonamide 
• 449761-01-7 2-chloro-N-methyl-5'-nitro-2'-[2-(1,2,3,4-tetrahydroisoquinolyl)]acetanilide 
• 449761-00-6 2-chloro-5'-nitro-N-methyl-2'-piperidinoacetanilide 
• 449760-99-0 2-chloro-5'-dimethylamino-N-methyl-5'-nitroacetanilide 
• 449760-92-3 2-dimethylamino-N-methyl-5-nitroaniline 
• 449760-93-4 N-methyl-5-nitro-2-piperidinoaniline 

Relevant articles and documents

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