110823-27-3Relevant academic research and scientific papers
Adamantylation and adamantylalkylation of amides, nitriles and ureas in trifluoroacetic acid
Shokova, Elvira,Mousoulou, Tasoulla,Luzikov, Yurij,Kovalev, Vladimir
, p. 1034 - 1040 (1997)
A new preparative method for N-adamantylation of carboxylic acid amides, ureas and for C5-adamantylation of barbituric acid in trifluoroacetic acid (TFA) is proposed. Tertiary 1-adamantanols and 1-(1-adamantyl)alkanols were used as adamantylating agents. The reaction of 1-(1-adamantyl)alkanols with nitriles in TFA solution was employed for the first time for the preparation of N-[1-(1-adamantyl)alkyl]amides.
Adamantylation and adamantylalkylation of amides, nitriles, and ureas in trifluoroacetic acid
Shokova,Musulu, Tasula,Luzikov,Kovalev
, p. 844 - 856 (2007/10/03)
A new preparative procedure was developed for N-adamantylation of carboxylic acids amides and ureas, and C5-adamantylation of barbituric acid in trifluoroacetic acid medium with tertiary adamantanols and 1-adamantylalkanols. The reaction of 2-adamantanols and secondary 1-adamantylalkanols with nitriles was for the first time used in the preparation of W-(2-adamantyl)-and N-(1-adamantylalkyl)amides.
