Synthesis p. 1034 - 1040 (1997)
Update date:2022-07-30
Topics: Amides Nitriles Trifluoroacetic acid Ureas
Shokova, Elvira
Mousoulou, Tasoulla
Luzikov, Yurij
Kovalev, Vladimir
A new preparative method for N-adamantylation of carboxylic acid amides, ureas and for C5-adamantylation of barbituric acid in trifluoroacetic acid (TFA) is proposed. Tertiary 1-adamantanols and 1-(1-adamantyl)alkanols were used as adamantylating agents. The reaction of 1-(1-adamantyl)alkanols with nitriles in TFA solution was employed for the first time for the preparation of N-[1-(1-adamantyl)alkyl]amides.
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