5048-64-6

Usage

Structure

2,2-dimethyl-1-[(4-methylphenyl)sulfonyl]aziridine

Type

sulfonyl-substituted aziridine

Usage

organic synthesis and pharmaceutical research

Applications

synthesis of various organic compounds (chiral building blocks and agrochemicals), development of novel drugs, precursor in the preparation of pharmaceuticals and agrochemicals

Additional role

chemical intermediate in the production of other organic compounds

Value

versatile reagent, valuable chemical in the field of organic synthesis and pharmaceutical research.

Upstream product

• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 115-11-7 isobutene 
• 124-68-5 2-Amino-2-methyl-1-propanol 
• 98-59-9 p-toluenesulfonyl chloride 
• 2658-24-4 2,2-dimethylaziridine 

Downstream Products

• 2951-60-2 N-(1,1-dimethyl-2-morpholin-4-yl-ethyl)-toluene-4-sulfonamide 
• 3052-95-7 4,4-dimethyl-3-(toluene-4-sulfonyl)-thiazolidine-2-thione 
• 110871-40-4 N-(3-methylbutan-2-yl)-4-methylbenzenesulfonamide 
• 98943-94-3 9-<2-methyl-2-(tosylamino)propyl>xanthene 
• 98943-91-0 9,9-bis<2-methyl-2-(tosylamino)propyl>xanthene 
• 85809-21-8 N-<1,1-Dimethyl-2-(fluorenyl-9)>-4-toluolsulfonamid 
• 98943-89-6 9-<2-methyl-2-(tosylamino)propyl>-9,10-dihydroanthracene 
• 98943-82-9 9,10-bis<2-methyl-2-(tosylamino)propyl>-9,10-dihydroanthracene 
• 108343-25-5 3,5,5-Trimethyl-2-oxo-1-(p-tolylsulfonyl)-3-pyrrolidincarbonitril 
• 108343-24-4 3,5,5-Trimethyl-2-oxo-1-(p-tolylsulfonyl)-3-pyrrolidincarboxamid 
• 108343-26-6 3,5,5-Trimethyl-2-oxo-1-(p-tolylsulfonyl)-3-pyrrolidincarbonsaeure-ethylester 
• 1206-41-3 N-(2-methylallyl)-4-toluenesulfonamide 
• 110871-37-9 4-methyl-N-(2-methyl-1-phenyl-propyl)-benzenesulfonamide 
• 110871-36-8 4-methyl-N-(2-methyl-1-phenylpropan-2-yl)benzenesulfonamide 

Relevant academic research and scientific papers

Radical Redox-Relay Catalysis: Formal [3+2] Cycloaddition of N-Acylaziridines and Alkenes

We report Ti-catalyzed radical formal [3+2] cycloadditions of N-acylaziridines and alkenes. This method provides an efficient approach to the synthesis of pyrrolidines, structural units prevalent in bioactive compounds and organocatalysts, from readily available starting materials. The overall redox-neutral reaction was achieved via a redox-relay mechanism, which harnesses radical intermediates for selective C - N bond cleavage and formation.

Generation and Ring Opening of Aziridines in Telescoped Continuous Flow Processes

A simple method for the preparation of a variety of N-sulfonyl aziridines (10 examples) from 1,2-amino alcohols under continuous flow conditions is described. Using flow based methods, the aziridines can be further ring opened with oxygen, carbon, and hal

Regio- and enantioselective aminofluorination of alkenes

Enantio- and regioselective: The intramolecular enantioselective aminofluorination of unactivated olefins was achieved by using a chiral iodo(III) difluoride salt. A highly regioselective aminofluorination of styrenes to access 2-fluoro-2-phenylethanamines was also developed. Copyright