5048-64-6

Basic information

• Product Name: 2,2-dimethyl-1-[(4-methylphenyl)sulfonyl]aziridine
• Synonyms: 2,2-Dimethyl-1-(toluene-4-sulfonyl)-aziridine; aziridine, 2,2-dimethyl-1-[(4-methylphenyl)sulfonyl]-
• CAS NO: 5048-64-6
• Molecular Formula: C₁₁H₁₅NO₂S
• Molecular Weight: 225.3073
• Mol File: 5048-64-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 326.1°C at 760 mmHg
• Flash Point: 151°C
• Density: 1.209g/cm³
• Vapor Pressure: 0.000221mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: 2,2-dimethyl-1-[(4-methylphenyl)sulfonyl]aziridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dimethyl-1-[(4-methylphenyl)sulfonyl]aziridine(5048-64-6)
• EPA Substance Registry System: 2,2-dimethyl-1-[(4-methylphenyl)sulfonyl]aziridine(5048-64-6)

Safety Data

• Hazardous Substances Data: 5048-64-6(Hazardous Substances Data)

Usage

Structure

2,2-dimethyl-1-[(4-methylphenyl)sulfonyl]aziridine

Type

sulfonyl-substituted aziridine

Usage

organic synthesis and pharmaceutical research

Applications

synthesis of various organic compounds (chiral building blocks and agrochemicals), development of novel drugs, precursor in the preparation of pharmaceuticals and agrochemicals

Additional role

chemical intermediate in the production of other organic compounds

Value

versatile reagent, valuable chemical in the field of organic synthesis and pharmaceutical research.

Upstream product

• 2658-24-4 2,2-dimethylaziridine 
• 98-59-9 p-toluenesulfonyl chloride 
• 124-68-5 2-Amino-2-methyl-1-propanol 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 115-11-7 isobutene 

Downstream Products

• 110871-38-0 4-methyl-N-(2-methyl-4-phenylbutan-2-yl)benzenesulfonamide 
• 110871-39-1 N-(1-benzyl-2-methylpropyl)-4-toluenesulfonamide 
• 87461-11-8 2-(4-Methylphenylsulfonylamino)-2-methylpropylphosphonsaeure-diethylester 
• 1206-41-3 N-(2-methylallyl)-4-toluenesulfonamide 
• 231944-87-9 N-[3-(dimethyl-phenyl-silanyl)-1,1-dimethyl-pent-4-enyl]-4-methyl-benzenesulfonamide 
• 1610361-07-3 4-methyl-N-(2-methyl-2-phenoxypropyl)benzenesulfonamide 
• 1610361-08-4 4-methyl-N-(2-methyl-1-phenoxypropan-2-yl)benzenesulfonamide 
• 1416056-29-5 7-[(N-p-tosyl)-2,2-dimethylethyloxy]coumarin 
• 1416056-27-3 4-[(N-p-tolylsulfonyl)-1,1-dimetylethyl]coumarin 
• 1190378-40-5 C₁₈H₂₃NO₂S₃ 
• 1190378-42-7 C₁₈H₂₃NO₂S₃ 
• 245751-89-7 5-Bromomethyl-2,2-dimethyl-1-(4-methylphenylsulfonyl)-4-(phenylthio)pyrrolidine 

Relevant articles and documents

Radical Redox-Relay Catalysis: Formal [3+2] Cycloaddition of N-Acylaziridines and Alkenes

We report Ti-catalyzed radical formal [3+2] cycloadditions of N-acylaziridines and alkenes. This method provides an efficient approach to the synthesis of pyrrolidines, structural units prevalent in bioactive compounds and organocatalysts, from readily available starting materials. The overall redox-neutral reaction was achieved via a redox-relay mechanism, which harnesses radical intermediates for selective C - N bond cleavage and formation.

Regio- and enantioselective aminofluorination of alkenes

Enantio- and regioselective: The intramolecular enantioselective aminofluorination of unactivated olefins was achieved by using a chiral iodo(III) difluoride salt. A highly regioselective aminofluorination of styrenes to access 2-fluoro-2-phenylethanamines was also developed. Copyright