1108730-69-3Relevant academic research and scientific papers
Iridium-Catalyzed Reductive Nucleophilic Addition to Secondary Amides
Takahashi, Yoshito,Yoshii, Risa,Sato, Takaaki,Chida, Noritaka
supporting information, p. 5705 - 5708 (2018/09/25)
An iridium-catalyzed reductive nucleophilic addition to secondary amides is reported. After the iridium-catalyzed reduction, the resulting imines can undergo the Strecker reaction, the Mannich reaction, allylation, and [3 + 2]-cycloaddition. The method sh
Evaluation of the heterogeneously catalyzed strecker reaction conducted under continuous flow
Wiles, Charlotte,Watts, Paul
experimental part, p. 5597 - 5613 (2009/05/11)
Building on our experience of micro-reaction technology, we present herein the evaluation of an integrated borosilicate glass micro reactor in which 51 α-aminonitriles were synthesized via a series of continuous solution-phase and heterogeneously catalyzed reaction steps, affording analytically pure products in yields > 99.6%. As an extension to this, the ability to selectivity synthesize aldehydic Strecker products in the presence of ketonic functionalities was also investigated, concluding with the chemoselective synthesis of 2-(4-acetylphenyl)-2-(phenethylamino)acetonitrile whereby the desired product was obtained in 99.8% yield and quantitative purity. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
