110907-85-2Relevant articles and documents
Direct synthesis of α-substituted phosphonates
Praveen Kumar, K,Muthiah, C,Kumaraswamy, Sudha,Kumara Swamy
, p. 3219 - 3221 (2007/10/03)
The α-substituted phosphonates (OCH2CMe2CH2O)P(O)CH(X)(Ar) [X=Cl, OMe, NMe2 and OSiMe3], useful precursors for Horner-Wadsworth-Emmons reactions, are readily prepared by treating (OCH2CMe2CH2O)PX with an aromatic aldehyde. In the reaction of (OCH2CMe2CH2O)PCl with furfuraldehyde and cinnamaldehyde, the 5-chlorofurfurylphosphonate (OCH2CMe2CH2O)P(O)CH2 (5-Cl-C4H2O) and the γ-chlorophosphonate (OCH2CMe2CH2O)P(O)CH=CH-CH(Cl)Ph, respectively, are formed in good yields.
Reaction of Cyclic Silyl Phosphites with Haloacetones
Morita, Iwao,Chokai, Shoichi,Tsuda, Masami,Kise, Masahiro,Sugiyama, Makoto
, p. 1135 - 1138 (2007/10/02)
The reaction of cyclic silyl phosphites (2) with haloacetones (3) was investigated.When oxirane compounds were used as scavengers of trimethylsilyl halides, cyclic acetonylphosphonates (4) were obtained directly.Treatment of 2-trimethylsilyloxy-1,3,2-dioxaphosphorinane (2a) with bromoacetone (3b) or iodoacetone (3c) in propylene oxide gave 4a in 24 percent and 41 percent yields, respectively.With cyclohexane oxide, the reaction of 2a with 3c in MeCN at reflux gave 4a in 50 percent yield.Treatment of 5,5-dimethyl-2-trimethylsilyloxy-1,3,2-dioxaphosphorinane (2b) with 3c in the same manner gave 4b in 43 percent yield.Keywords - cyclic silyl phosphite; haloacetone; cyclic acetonylphosphonate; enolphosphate; Arbuzov reaction; Perkow reaction; carbonyl adduct; trimethylsilyl halide scavenger