110969-43-2Relevant academic research and scientific papers
Ag+ mediated deaminations of N-Boc aryl hydrazines for the efficient synthesis of N-Boc aryl amines
Lee, Kang-Sang,Lim, Young-Kwan,Cho, Cheon-Gyu
, p. 7463 - 7464 (2002)
N-Boc-aryl hydrazines were converted into N-Boc-aryl amines under the action of Ag+. Its mild reaction conditions tolerate the presence of a variety of functional groups.
Palladium-catalyzed amidation of aryl halides using 2-dialkylphosphino- 2′-alkoxyl-1,1′-binaphthyl as ligands
Ma, Fangfang,Xie, Xiaomin,Zhang, Lei,Peng, Zhiyong,Ding, Lina,Fu, Lei,Zhang, Zhaoguo
experimental part, p. 5279 - 5285 (2012/08/07)
Palladium-catalyzed intermolecular C-N bond-forming reactions between aryl halides and amides are described using 2-dialkylphosphino-2′-alkoxyl-1, 1′-binaphthyl, which is both bulky and electron-rich, as the ligand. A variety of amides, including aliphatic and aromatic primary amides, lactams, and carbamates, were viable substrates for the amidation, which exhibited good functional group compatibility. By tuning the substituents at the 2,2′-position of 1,1′-binaphthyl of the ligand, the palladium-catalyzed amidation of bulky aryl halides was realized and this coupling reaction was used to synthesize 2-amino-2′-methoxy-1,1′- binaphthyl in high yield.
Room-temperature Pd-catalyzed amidation of aryl bromides using tert-butyl carbamate
Bhagwanth, Swapna,Waterson, Alex G.,Adjabeng, George M.,Hornberger, Keith R.
supporting information; experimental part, p. 4634 - 4637 (2009/09/08)
(Chemical Equation Presented) The scope of Pd-catalyzed synthesis of N-Boc-protected anilines from aryl bromides and commercially available tertbutyl carbamate is described. For the first time, this process can be conducted at room temperature (17-22°C) u
Aryl-chloro-ethyl ureas
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Page/Page column 8-9; 10, (2008/06/13)
Described herein are novel 1-aryl-3-(2-chloroalkanylureas derivatives. These derivatives are useful anticaner agents having excellent specifilty towards cell targets and potent antineoplastic activity without systemic toxicity derivatives mutagenicity. Mo
A New Generation of N-Aryl-N′-(1-alkyl-2-chloroethyl)ureas as Microtubule Disrupters: Synthesis, Antiproliferative Activity, and β-Tubulin Alkylation Kinetics
Mounetou, Emmanuelle,Legault, Jean,Lacroix, Jacques,Gaudreault, René C.
, p. 5055 - 5063 (2007/10/03)
New N-aryl-N′-2-chloroethylureas (CEUs) with enhanced cytotoxicity were developed as antimitotic agents potentially useful in cancer chemotherapy. Highly potent CEUs were obtained by introduction of a branched alkylating chain, the N′-(1-methyl-2-chloro)e
Selective Cleavage of Boc-acylamides. A Novel Approach to Deacylation of Carboxamides
Grehn, Leif,Gunnarsson, Kerstin,Ragnarsson, Ulf
, p. 18 - 23 (2007/10/02)
Boc (tert-butoxycarbonyl) derivatives were recently prepared from various amides.This paper describes some of their properties with particular attention to mild amide cleavage.Boc-protected carboxamides were cleaved by aminolysis with complete selectivity to give the corresponding tert-butyl carbamates.The amines used ranged from hydrazine to morpholine, but for preparative purposes 2-diethylaminoethylamine was preferred.A simple two-step one-pot procedure for tert-butoxycarbonylation followed by aminolysis was developed which could be used for removal of formyl, ace tyl, and benzoyl groups.In extreme cases, there derivatives were cleaved by alcoholysis.Upon addition of bases such as N,N,N',N'-tetramethylguanidine (TMS) this reaction became very fast.TMS-catalysed methanolysis gave 98percent cleavage in 30 min or less in two preparative experiments.
