110991-77-0

Basic information

• Product Name: methyl 4-((2-chloroethyl)amino)-3,5-dinitrobenzoate
• Synonyms: methyl 4-((2-chloroethyl)amino)-3,5-dinitrobenzoate
• CAS NO: 110991-77-0
• Molecular Weight: 303.659
• Mol File: 110991-77-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 4-((2-chloroethyl)amino)-3,5-dinitrobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-((2-chloroethyl)amino)-3,5-dinitrobenzoate(110991-77-0)
• EPA Substance Registry System: methyl 4-((2-chloroethyl)amino)-3,5-dinitrobenzoate(110991-77-0)

Safety Data

• Hazardous Substances Data: 110991-77-0(Hazardous Substances Data)

Upstream product

• 2552-45-6 methyl 4-chloro-3,5-dinitrobenzoate 
• 870-24-6 2-chloroethanamine hydrochloride 

Relevant articles and documents

Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent

Our first generation of hydroxyethylamine transition-state mimetic BACE-1 inhibitors allowed us to validate BACE-1 as a key target for Alzheimer's disease by demonstrating amyloid lowering in an animal model, albeit at rather high doses. Finding a molecul

HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE

The present invention relates to novel hydroxyethylamine compounds of formula (I): (I) having Asp2 (-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated-amyloid levels or-amyloid deposits, particularly Alzheimer's disease.