2552-45-6Relevant academic research and scientific papers
HIGHLY ACTIVE STING PROTEIN AGONIST COMPOUND
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Paragraph 0410-0412, (2021/07/17)
The present invention provides compounds of Formula (I) or (II), pharmaceutical compositions thereof, and methods of using compounds of Formula (I) or (II) to prevent and/or treat immune-related disorders.
ANTI-INFECTIVE HETEROCYCLIC COMPOUNDS AND USES THEREOF
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Page/Page column 9; 110; 111, (2018/04/11)
The present invention relates to heterocyclic compounds of Formula I useful as anti-infective agents. The present invention further relates to a method of treating an infection by administering such compounds, and to pharmaceutical compositions comprising such compounds.
DENDRITIC COMPOUNDS INCLUDING A CHELATING, FLUOROCHROME OR RECOGNITION AGENT, COMPOSITIONS INCLUDING SAME AND USES THEREOF
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Paragraph 0350; 0351; 0352, (2016/08/29)
The invention relates to dendritic compounds comprising a chelating, fluorochrome or recognition agent of formula (I), to compositions comprising same, and to uses thereof, wherein in said formula (I): T, L1, D, R, L2, V and n are as defined in the description.
Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent
Charrier, Nicolas,Clarke, Brian,Demont, Emmanuel,Dingwall, Colin,Dunsdon, Rachel,Hawkins, Julie,Hubbard, Julia,Hussain, Ishrut,Maile, Graham,Matico, Rosalie,Mosley, Julie,Naylor, Alan,O'Brien, Alistair,Redshaw, Sally,Rowland, Paul,Soleil, Virginie,Smith, Kathrine J.,Sweitzer, Sharon,Theobald, Pam,Vesey, David,Walter, Daryl S.,Wayne, Gareth
scheme or table, p. 3669 - 3673 (2010/03/24)
Our first generation of hydroxyethylamine transition-state mimetic BACE-1 inhibitors allowed us to validate BACE-1 as a key target for Alzheimer's disease by demonstrating amyloid lowering in an animal model, albeit at rather high doses. Finding a molecul
Discovery and optimization of antibacterial AccC inhibitors
Cheng, Cliff C.,Shipps Jr., Gerald W.,Yang, Zhiwei,Sun, Binyuan,Kawahata, Noriyuki,Soucy, Kyle A.,Soriano, Aileen,Orth, Peter,Xiao, Li,Mann, Paul,Black, Todd
scheme or table, p. 6507 - 6514 (2010/05/17)
The biotin carboxylase (AccC) is part of the multi-component bacterial acetyl coenzyme-A carboxylase (ACCase) and is essential for pathogen survival. We describe herein the affinity optimization of an initial hit to give 2-(2-chlorobenzylamino)-1-(cyclohe
Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators
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Page/Page column 37-38, (2008/06/13)
The invention provides for a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1, R2, R3, A, B, D, m, n, x, and y are defined as described in the specification. The invention additionally provides a pharmaceutically composition comprising the compound of formula I, together with a method of using the same to treat or prevent neurological and psychiatric disorders. The compounds are useful in therapy related to the treatment or prevention of mGluR2 receptor-mediated disorders.
Synthesis and antibacterial activity of some substituted 3-(aryl)- and 3-(heteroaryl)indoles
Al-Hiari, Yusuf M.,Qaisi, Ali M.,El-Abadelah, Mustafa M.,Voelter, Wolfgang
, p. 243 - 248 (2007/10/03)
A synthesis of 3-(4-methoxycarbonyl-2,6-dinitrophenyl)indole, its 2,6-diamino analog, and 3-(2-amino-4-trifluoromethyl-6-nitrophenyl)indole is described. 4-(Trifluoromethyl)phenyl derivatives exhibit higher antibacterial potency than the former 4-(methoxy
Effects of ortho- and para-ring activation on the kinetics of S NAr reactions of 1-chloro-2-nitro- and 1-phenoxy-2-nitrobenzenes with aliphatic amines in acetonitrile
Crampton, Michael R.,Emokpae, Thomas A.,Isanbor, Chukwuemeka,Batsanov, Andrei S.,Howard, Judith A. K.,Mondal, Raju
, p. 1222 - 1230 (2007/10/03)
Rate constants are reported for reaction of 4-substituted 1-chloro-2,6-dinitrobenzenes 1, 6-substituted 1-chloro-2,4-dinitrobenzenes 2, and some of the corresponding 1-phenoxy derivatives, 3 and 4, with n-butylamine, pyrrolidine and pi-peridine in acetoni
HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE
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Page 25, (2010/02/07)
The present invention relates to novel hydroxyethylamine compounds of formula (I): (I) having Asp2 (-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated-amyloid levels or-amyloid deposits, particularly Alzheimer's disease.
Synthesis of Polyfunctionalized Biphenyls as Intermediates for a New Class of Liquid Crystals
Manka, Jason T.,Guo, Fengli,Huang, Jianping,Yin, Huiyong,Farrar, John M.,Sienkowska, Monika,Benin, Vladimir,Kaszynski, Piotr
, p. 9574 - 9588 (2007/10/03)
A series of hexa- and octasubstituted biphenyls containing halogen, amino, nitro, and propylthio substituents were prepared by metal-mediated convergent synthesis from halobenzene precursors. The Pd-assisted C-C coupling methods were ineffective in the fo
