111-47-7

Usage

Uses

Used in Organic Synthesis:
Propyl sulfide is used as an intermediate in the synthesis of various organic compounds. Its chemical properties make it a versatile building block for creating a wide range of molecules with different functionalities.
Used in Fragrance Industry:
Propyl sulfide is used as a component in the daily fragrance industry. Its pleasant aroma and stability make it a suitable addition to perfumes and other scented products.
Used in Pharmaceutical Industry:
As a garlic organosulfide, propyl sulfide may have potential applications in the pharmaceutical industry, particularly in the development of drugs targeting various health conditions. However, more research is needed to fully understand its therapeutic potential and safety profile.

Synthesis Reference(s)

Canadian Journal of Chemistry, 51, p. 1419, 1973 DOI: 10.1139/v73-213Organic Syntheses, Coll. Vol. 2, p. 547, 1943Tetrahedron Letters, 20, p. 3995, 1979

Purification Methods

Wash the sulfide with aqueous 5% NaOH, then water. Dry it with CaCl2 and distil it from Na [Dunstan & Griffiths J Chem Soc 1344 1962]. [Beilstein 1 IV 1452.]

InChI:InChI=1/C6H14S/c1-3-5-7-6-4-2/h3-6H2,1-2H3

Upstream product

• 71-23-8 propan-1-ol 
• 56-23-5 tetrachloromethane 
• 107-03-9 1-thiopropane 
• 187737-37-7 propene 
• 592-88-1 diallyl sulphide 
• 33922-80-4 bis-(1-propenyl) sulfide 
• 106-94-5 propyl bromide 
• 17356-08-0 thiourea 
• 74-98-6 propane 
• 6028-61-1 dipropyl trisulfide 
• 4253-91-2 dipropyl sulfoxide 
• 107-08-4 1-iodo-propane 
• 7783-06-4 hydrogen sulfide 
• 78-00-2 tetraethyllead(IV) 

Downstream Products

• 17626-99-2 S,S-dipropyl-N-(toluene-4-sulfonyl)-sulfimide 
• 107-03-9 1-thiopropane 
• 7789-89-1 1,1,1-trichloropropane 
• 598-03-8 propyl sulfone 
• 79-05-0 Propionamid 
• 4253-91-2 dipropyl sulfoxide 
• 64036-94-8 ethoxycarbonylmethyl-dipropyl sulfonium ; bromide 
• 38178-50-6 dipropyl phenacyl sulfonium bromide 
• 70064-36-7 1,1-Diphenyl-2-propylsulfanyl-butan-1-ol 
• 591-50-4 iodobenzene 
• 120188-80-9 C₇H₁₇OS⁽¹⁺⁾*C₇H₇O₃S^(1-) 
• 70-55-3 toluene-4-sulfonamide 
• 75-73-0 carbon tetrafluoride 
• 76-19-7 freon-218 

Relevant academic research and scientific papers

The reaction of (η-C5H5)2Ti(CO)2 with sulfoxides

Sulfoxides are reduced by (η-C5H5)2Ti(CO)2 to give sulfides in high yield while sulfones and phosphine oxides do not react.

Reactions of Dichloroethenes with Sulfur in the System Hydrazine Hydrate–KОН

Vinylidene chloride and 1,2-dichloroethene react with sulfur in the system hydrazine hydrate–KОН with the formation of polyvinylenesulfide oligomer of molecular mass 1750–6120 Da containing also vinylenehydrazine and vinylenechloride links in the Z-configuration, and 1,4-dithiine in the yield up to 46%. In aqueous-hydrazine layer polysulfide anions Sn2– (n = 1–4), mainly S22– were found. The mechanism of formation of oligomers and 1,4-dithiine is suggested, which includes in the first stage dehydrochlorination of dichloroethenes and generation of chloroacetylene.

Bis(tributyltin) Sulfide: An Effective and General Sulfur-Transfer Reagent

Bis(tributyltin) sulfide acts efficiently to transfer the sulfur atom as S(2-) to a variety of halide substrates to afford the corresponding symmetrical sulfides in good overall yield.

A process for the preparation of isoflavones propanethiol

The invention discloses a method for synthesizing isopropyl mercaptan from propylene and hydrogen sulfide. According to the method, a heat insulation type fixed bed reactor is used and isopropyl mercaptan is synthesized of hydrogen sulfide and propylene in the presence of a solid acid catalyst according to a continuous production process. The method disclosed by the invention has the advantages that the reaction conditions are easy to control, the yield is high, the process is simple, and the environmental pollution is reduced.

Dithiooxamide as an Effective Sulfur Surrogate for Odorless High-Yielding Carbon-Sulfur Bond Formation in Wet PEG200 as an Eco-Friendly, Safe, and Recoverable Solvent

In this study, we have employed dithiooxamide, a solid, odorless, and commercially available compound, as a sulfur surrogate for the preparation of dialkyl sulfides from available alkyl halides in high yields. This sulfur transfer agent was also used for a copper-catalyzed high-yielding preparation of diaryl sulfides from their available aryl halides and for the preparation of thia-Michael adducts in high yields. All the reactions were performed under odorless conditions in wet PEG200 (PEG = polyethylene glycol), which is an eco-friendly, safe, and recoverable solvent. The protocols were easily applicable to large-scale operation.

Hydrogenation of sulfoxides to sulfides under mild conditions using ruthenium nanoparticle catalysts

The first demonstration of the hydrogenation of sulfoxides under atmospheric H2 pressure is reported. The highly efficient reaction is facilitated by a heterogeneous Ru nanoparticle catalyst. The mild reaction conditions enable the selective hydrogenation of a wide range of functionalized sulfoxides to the corresponding sulfides. The high redox ability of RuO x nanoparticles plays a key role in the hydrogenation.

Highly efficient deoxygenation of sulfoxides using hydroxyapatite-supported ruthenium nanoparticles

We report the first example of the deoxygenation of sulfoxides using heterogeneous catalysts with alcohols as environmentally friendly reducing reagents. Hydroxyapatitesupported Ru nanoparticles (RuNPs/HAP) act as a highly efficient and reusable heterogeneous catalyst for deoxygenation of sulfoxides using alcohols as reductants. The catalytic activity of Ru nanoparticles is outstanding compared to other metal nanoparticles such as Pt, Pd, Rh, and Au nanoparticles. RuNPs/HAP can also catalyze the selective deoxygenation of various sulfoxides, giving the corresponding sulfides in excellent yields.

Cyanuric chloride as promoter for the oxidation of sulfides and deoxygenation of sulfoxides

This Letter discusses the use of cyanuric chloride as an efficient promoter for the chemoselective oxidation of sulfides to the corresponding sulfones in the presence of H2O2 as the terminal oxidant. Sulfoxides were also found to undergo deoxygenation to sulfides with cyanuric chloride and potassium iodide system. The reaction is broad in scope and easy to perform.

Process and catalyst for synthesis of mercaptans and sulfides from alcohols

A process and catalyst blend for selectively producing mercaptans and sulfides from alcohols. The alcohol is reacted with hydrogen sulfide, in the presence of a catalyst blend containing a hydrotreating catalyst and a dehydration catalyst to convert the alcohol to mercaptan or sulfide in one-pass. The alcohols can include primary and secondary alcohols. The mercaptan or sulfide having less than about 30% unreacted alcohol contained therein.

New ways of synthesis of 1,2-dithiole-3-thione

Two new synthetic approaches to 1,2-dithiole-3-thione are proposed. The title compound is formed by thermolysis of dipropyl polysulfides (n-Pr) 2Sx (x = 3-4) and thermal decomposition of polysulfide dendrimers under reduced pressure. The latter reaction may be recommended for utilization of organochlorine waste products in the manufacture of epichlorohydrin, which are used for the synthesis of dendrimers. 2004 MAIK "Nauka/Interperiodica".