111003-36-2

Usage

Uses

Used in Chemical Industry:
((2R,3S)-3-propyloxiran-2-yl)methanol is used as a key intermediate in the production of polyurethanes, which are versatile polymers with applications in various industries such as furniture, automotive, and construction.
Used in Solvent Production:
It is also utilized as a starting material for the synthesis of solvents, which are essential in numerous industrial processes, including cleaning, degreasing, and as a medium for chemical reactions.
Used in Pharmaceutical Industry:
Due to its unique chiral structure, ((2R,3S)-3-propyloxiran-2-yl)methanol may have potential applications in the development of chiral drugs, where the stereochemistry of a molecule can significantly impact its biological activity and efficacy.
Used in Research and Development:
As a chiral molecule, ((2R,3S)-3-propyloxiran-2-yl)methanol can be employed in research and development for understanding the effects of stereochemistry on chemical reactions and the properties of synthesized compounds.

Upstream product

• 928-95-0 (E)-2-Hexen-1-ol 

Downstream Products

• 944716-73-8 (2S,3S)-N-cyclopropyl-3-amino-2-hydroxyhexanoic acid amide hydrochloride 
• 402959-36-8 C₃₆H₅₅N₇O₆ 
• 402957-28-2 (1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide 
• 110918-75-7 (2S,3S,4R)-2,4-dimethyl-3-tetrahydropyranyloxyheptyl tosylate 
• 125414-62-2 (4R,5S)-4-Hydroxymethyl-5-propyl-oxazolidin-2-one 
• 110918-65-5 (2'R,3'S)-2',3'-epoxyhexyl 3,5-dinitrobenzoate 
• 110918-68-8 (2S,3R)-3-methyl-1-tosyloxy-2-hexanol 
• 94992-81-1 (2R,3R)-3-Methyl-hexane-1,2-diol 
• 76741-12-3 (2S,3R)-3-methylhexane-1,2-diol 
• 76741-13-4 (2R,3S)-3-methylhexane-1,2-diol 
• 105-31-7 (3R)-hex-1-yn-3-ol 
• 105-31-7 (S)-(-)-1-hexyn-3-ol 

Relevant academic research and scientific papers

Process for cooxidizing organic compounds, process for producing epoxy compounds and process for producing esters or lactones

According to the inventive co-oxidation process of organic compounds, (A) a compound selected from (A1) a compound having a non-aromatic ethylenic bond and (A2) a ketone or an alcohol corresponding to the ketone is oxidized by molecular oxygen in the presence of N-hydroxyphthalimide or another imide compound and in the coexistence of (B) a compound oxidizable by the imide compound and oxygen and different from the compound (A). As the compound (B), (a) primary or secondary alcohols (e.g., benzhydrol, cyclohexanol), (b) compounds each having a carbon-hydrogen bond at the adjacent position to an unsaturated bond (e.g., tetralin, ethylbenzene) and the like can be used. According to this process, a corresponding epoxy compound from the compound (A1) having a non-aromatic ethylenic bond, and a corresponding ester or lactone from the ketone or its corresponding alcohol (A2) can be obtained in satisfactory yields.

Mechanism of asymmetric epoxidation. 1. Kinetics

The rate of titanium-tartrate-catalyzed asymmetric epoxidation of allylic alcohols is shown to be first order in substrate and oxidant, and inverse second order in inhibitor alcohol, under pseudo-first-order conditions in catalyst. The rate is slowed by substitution of electron-withdrawing substituents on the olefin and varies slightly with solvent, CH2Cl2 being the solvent of choice. Asymmetric induction suffers when the size of the alkyl hydroperoxide is reduced. Kinetic resolution of secondary allylic alcohols is shown to be sensitive to the size of the tartrate ester group and insensitive to the steric nature of inhibitor alcohol. Most importantly, the species containing equimolar amounts of Ti and tartrate is shown to be the most active catalyst in the reaction mixture, mediating reaction at much faster rates than titanium tetraalkoxide alone.