111005-65-3

Basic information

• Product Name: (1R,2R)-1,2-Dihydroxy-3-cyclopropen-5-one 1,2-Cyclohexyl Ketal
• Synonyms: (1R,2R)-1,2-Dihydroxy-3-cyclopropen-5-one 1,2-Cyclohexyl Ketal;(3'aR,6'aR)-3'a,6'a-Dihydro-spiro[cyclohexane-1,2'-[4H]cyclopenta[1,3]dioxol]-4'-one
• CAS NO: 111005-65-3
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.22706
• Product Categories: Chiral reagents;Inhibitors;Intermediates
• Mol File: 111005-65-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• Stability: Moisture Sensitive
• CAS DataBase Reference: (1R,2R)-1,2-Dihydroxy-3-cyclopropen-5-one 1,2-Cyclohexyl Ketal(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-1,2-Dihydroxy-3-cyclopropen-5-one 1,2-Cyclohexyl Ketal(111005-65-3)
• EPA Substance Registry System: (1R,2R)-1,2-Dihydroxy-3-cyclopropen-5-one 1,2-Cyclohexyl Ketal(111005-65-3)

Safety Data

• Hazardous Substances Data: 111005-65-3(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Mannostatin intermediate.

Upstream product

• 111005-67-5 (3R,4S,5S)-3,4-O-cyclohexylidenecyclopentane-3,4,5-triol 
• 194609-14-8 (3S,4S,5R,6R)-4,5-O-cyclohexylidene-3,4,5,6,7-pentahydroxyhex-1-ene 
• 108-94-1 cyclohexanone 
• 123168-27-4 2,3-O-cyclohexylidene-D-ribofuranose 
• 186803-48-5 2,3-O-cyclohexylidene-L-(-)-erythruronic acid 
• 756-79-6 dimethyl methane phosphonate 
• 186790-80-7 2,3-(cyclohexylidenedioxy)-4-hydroxy-4-(2-propyloxy)butanoic acid lactone 
• 27304-20-7 2,3-O-cyclohexylidene-γ-D-ribonolactone 

Downstream Products

• 141089-74-9 (2R,3R,4R)-2,3-(cyclohexylidenedioxy)-4-phenylcyclopentanone 
• 1440509-94-3 C₂₈H₄₂N₈O₃ 
• 72877-50-0 neplanocin A 
• 19186-33-5 aristeromycin 
• 141089-81-8 (1'R,2'S,3'R,4'R)-9-<2',3'-(cyclohexylidenedioxy)-4'-phenylcyclopentan-1'-yl>adenine 
• 141089-69-2 (1'R,2'S,3'R,4'R)-9-(2',3'-dihydroxy-4'-phenylcyclopentan-1'-yl)adenine 
• 141089-78-3 (1S,2S,3R,4R)-2,3-(cyclohexylidenedioxy)-4-phenylcyclopentanol 
• 111005-68-6 (-)-2,3-(cyclohexylidenedioxy)-1-<(p-tolylsulfonyl)oxy>cyclopent-4-ene 
• 111005-71-1 (-)-9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl)-3-deazaadenine 
• 111005-70-0 (-)-9β-(2'α,3'α-dihydroxypent-4'-enyl)adenine 
• 1054655-84-3 C₃₈H₄₈N₂O₈S 
• 210699-84-6 C₂₃H₂₈N₄O₅ 
• 210699-82-4 1-{(1'R,2'S,3'R,4'R)-4-[(benzyloxy)methyl]-2,3-(cyclohexylidenedioxy)cyclopentan-1-yl}uracil 
• 210699-85-7 C₂₃H₂₆N₂O₅ 

Relevant articles and documents

Reinvestigation of the synthesis of (2R,3R) 2,3-(cyclohexylidenedioxy)-4-cyclopentenone as possible building block for the synthesis of carbocyclic nucleosides

An in depth study of the four-steps synthesis of (2R,3R) 2,3-(cyclohexylidenedioxy)-4-cyclopentenone (5) from D-ribonolactone (1) is described. From these experiments we must conclude that the overall yield reported in the literature (65%) is overestimated. All compounds have been throughly investigated by 1H- and 13C-NMR spectroscopy.

NON-RIBOSE CONTAINING INHIBITORS OF HISTONE METHYLTRANSFERASE DOT1L FOR CANCER TREATMENT

A compound of Formula I, a pharmaceutically acceptable salt thereof, a prodrug thereof, or combinations thereof: wherein R1 is H, methyl, or benzyl: R2 is 2-cyanoethyl, 2-methoxycarbonylethyl, or 2-iodoethyl; X is N or S; wherein if

Synthesis of analogues of neplanocin A: Utilization of optically active dihydroxycyclopentenones derived from carbohydrates

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