Short and efficient synthesis of enantiomerically pure building blocks for the preparation of carbocyclic nucleosides and prostaglandins via diastereoselective dihydroxylation of 5-menthyloxy-2[5H]-furanone

Article abstract of DOI:10.1016/0957-4166(96)00240-6

A short and efficient synthesis of both enantiomerically pure 2,3-(Cyclohexylidenedioxy)-4-cyclopentenones 4 and ent-4 from the readily available 5-menthyloxy-2[5H]-furanones 1 and ent-1 is presented. The key step is the substrate controlled diastereosele