111026-47-2

Upstream product

• 103-63-9 1-phenyl-2-bromoethane 
• 104-47-2 p-methoxybenzylnitrile 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 93031-12-0 ethyl phenethylcyanoacetate 
• 1209495-01-1 rac-1-cyano-3-phenylpropyl trifluoromethanesulfonate 
• 5720-07-0 4-methoxyphenylboronic acid 

Downstream Products

• 111026-96-1 3-(4-acetoxyphenyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 
• 111026-94-9 3-(4-Methoxy-phenyl)-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 
• 111026-95-0 3-(4-Hydroxy-phenyl)-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 
• 111026-82-5 2-(4-Hydroxy-phenyl)-3,4-dihydro-2H-naphthalen-1-one oxime 
• 111027-07-7 N-hydroxy-2-(4'-methoxyphenyl)tetralone oxime 
• 3261-92-5 2-(4'-methoxyphenyl)-α-tetralone 
• 3261-93-6 2-(4-hydroxyphenyl)-1-tetralone 
• 3261-91-4 2-(4-methoxyphenyl)-4-phenylbutyric acid 

Relevant academic research and scientific papers

Assembly of α-(Hetero)aryl Nitriles via Copper-Catalyzed Coupling Reactions with (Hetero)aryl Chlorides and Bromides

α-(Hetero)aryl nitriles are important structural motifs for pharmaceutical design. The known methods for direct synthesis of these compounds via coupling with (hetero)aryl halides suffer from narrow reaction scope. Herein, we report that the combination of copper salts and oxalic diamides enables the coupling of a variety of (hetero)aryl halides (Cl, Br) and ethyl cyanoacetate under mild conditions, affording α-(hetero)arylacetonitriles via one-pot decarboxylation. Additionally, the CuBr/oxalic diamide catalyzed coupling of (hetero)aryl bromides with α-alkyl-substituted ethyl cyanoacetates proceeds smoothly at 60 °C, leading to the formation of α-alkyl (hetero)arylacetonitriles after decarboxylation. The method features a general substrate scope and is compatible with various functionalities and heteroaryls.

A novel class of potential central nervous system agents. 3-Phenyl-2-(1-piperazinyl)-5H-1-benzazepines

A series of 3-phenyl-2-piperazinyl-5H-1-benzazepines and related compounds were synthesized and evaluated for potential neuroleptic activity. The preparation of these compounds was carried out by 2,3-dichlorination of 3-phenyl-2,3,4,5-tetrahydro-1H-1-benz