111080-48-9

Basic information

• Product Name: (2-HYDROXYMETHYL-PHENOXY)-ACETIC ACID ETHYL ESTER
• Synonyms: ACETIC ACID, 2[2-(HYDROXYMETHYL)PHENOXY]-, ETHYL ESTER
• CAS NO: 111080-48-9
• Molecular Formula: C₁₁H₁₄O₄
• Molecular Weight: 210.23
• Mol File: 111080-48-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (2-HYDROXYMETHYL-PHENOXY)-ACETIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (2-HYDROXYMETHYL-PHENOXY)-ACETIC ACID ETHYL ESTER(111080-48-9)
• EPA Substance Registry System: (2-HYDROXYMETHYL-PHENOXY)-ACETIC ACID ETHYL ESTER(111080-48-9)

Safety Data

• Hazardous Substances Data: 111080-48-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 24, p. 495, 1987 DOI: 10.1002/jhet.5570240236

Upstream product

• 90-02-8 salicylaldehyde 
• 90-01-7 salicylic alcohol 
• 105-36-2 ethyl bromoacetate 
• 41873-61-4 ethyl (2-formylphenoxy)acetate 

Downstream Products

• 111080-49-0 o-(ethoxycarbonylmethoxy)benzyl chloride 
• 506444-34-4 2-(2-{2-[2-(2-hydroxy-ethoxy)-benzylsulfanyl]-ethylsulfanylmethyl}-phenoxy)-ethanol 
• 506444-32-2 {2-[2-(2-ethoxycarbonylmethoxy-benzylsulfanyl)-ethylsulfanylmethyl]-phenoxy}-acetic acid ethyl ester 
• 506444-35-5 2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-benzylsulfanyl]-ethylsulfanyl}-ethylsulfanylmethyl)-phenoxy]-ethanol 
• 506444-33-3 (2-{2-[2-(2-ethoxycarbonylmethoxy-benzylsulfanyl)-ethylsulfanyl]-ethylsulfanylmethyl}-phenoxy)-acetic acid ethyl ester 
• 506444-36-6 C₂₀H₂₆S₂O₄(SO₂C₇H₆)2 
• 506444-37-7 C₂₀H₂₆S₂O₄(SO₂C₇H₆)2C₂H₄S 
• 43119-53-5 ethyl 2,3-dihydro-1-benzofuran-2-carboxylate 
• 1914-60-9 2,3-dihydro-1-benzofuran-2-carboxylic acid 
• 97388-49-3 (2-hydroxymethyl-phenoxy)-acetic acid 

Relevant articles and documents

Biobased High-Performance Aromatic-Aliphatic Polyesters with Complete Recyclability

The development of high-performance recyclable polymers represents a circular plastics economy to address the urgent issues of plastic sustainability. Herein, we design a series of biobased seven-membered-ring esters containing aromatic and aliphatic moie

Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin

Plasmepsin (Plm) is a potential target for new antimalarial drugs, but most reported Plm inhibitors have relatively low antimalarial activities. We synthesized a series of dipeptide-type HIV protease inhibitors, which contain an allophenylnorstatine-dimethylthioproline scaffold to exhibit potent inhibitory activities against Plm II. Their activities against Plasmodium falciparum in the infected erythrocyte assay were largely different from those against the target enzyme. To improve the antimalarial activity of peptidomimetic Plm inhibitors, we attached substituents on a structure of the highly potent Plm inhibitor KNI-10006. Among the derivatives, we identified alkylamino compounds such as 44 (KNI-10283) and 47 (KNI-10538) with more than 15-fold enhanced antimalarial activity, to the sub-micromolar level, maintaining their potent Plm II inhibitory activity and low cytotoxicity. These results suggest that auxiliary substituents on a specific basic group contribute to deliver the inhibitors to the target Plm.

A practical synthesis of 2,3-dihydro-2-benzofurancarboxylic acid: A general route to 2,3-dihydrobenzofurans

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