111102-47-7

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 74-11-3 para-chlorobenzoic acid 
• 122-01-0 4-chloro-benzoyl chloride 

Downstream Products

• 321681-30-5 N-(4-chlorobenzoyl)-2-(4-chlorophenyl)benzimidazole 
• 1019-85-8 2-(4-chlorophenyl)benzimidazole 

Relevant academic research and scientific papers

Efficient propylphosphonic anhydride (T3P) mediated synthesis of benzothiazoles, benzoxazoles and benzimidazoles

Propylphosphonic anhydride (T3P) promotes cyclization of o-aminobenzenethiol, o-aminophenol, and o-phenylenediamine with carboxylic acids under microwave irradiation. The one-pot procedure is efficient and allows short reaction times, easy workup, and good yields. Thus, we describe here a method for quick preparation of benzothiazoles, benzoxazoles and benzimidazoles.

Mass spectrometer as a probe in the synthesis of 2-substituted benzimidazoles

The pyrolysis of N,N'-diacyl-1,2-benzenediamines leads to the formation of 2-substituted benzimidazoles. This new synthetic approach towards the synthesis of 2-substituted benzimidazoles is developed based on the electron impact studies of N,N'-diacyl-1,2-benzenediamines under 70 eV conditions, in which important fragment ions corresponding to 2-substituted benzimidazoles are observed. The mechanisms and ion-structures, proposed in the mass spectral study, are supported by high-resolution, B/E and B2/E linked-scan spectra and Collision Activated Decomposition (CAD)-B/E linked-scan spectra.