111105-19-2

Upstream product

• 2969-81-5 Ethyl 4-bromobutyrate 
• 95-57-8 2-monochlorophenol 
• 999-10-0 ethyl 4-hydroxybutanoate 
• 64-17-5 ethanol 
• 201230-82-2 carbon monoxide 
• 20788-42-5 allyl 2-chlorophenyl ether 

Downstream Products

• 5057-52-3 4-(2-chlorophenoxy)butanoic acid 

Relevant academic research and scientific papers

Identification of 5-Substituted 2-Acylaminothiazoles That Activate Tat-Mediated Transcription in HIV-1 Latency Models

The persistent reservoir of cells latently infected with human immunodeficiency virus (HIV)-integrated proviral DNA necessitates lifelong suppressive antiretroviral therapy (ART). Epigenetic targeted compounds have shown promise as potential latency-reversing agents; however, these drugs have undesirable toxicity and lack specificity for HIV. We utilized a novel HEK293-derived FlpIn dual-reporter cell line, which quantifies specific HIV provirus reactivation (LTR promoter) relative to nonspecific host cell gene expression (CMV promoter), to identify the 5-substituted 2-acylaminothiazole hit class. Here, we describe the optimization of the hit class, defining the functionality necessary for HIV gene activation and for improving in vitro metabolism and solubility. The optimized compounds displayed enhanced HIV gene expression in HEK293 and Jurkat 10.6 latency cellular models and increased unspliced HIV RNA in resting CD4+ T cells isolated from HIV-infected individuals on ART, demonstrating the potential of the 2-acylaminothiazole class as latency-reversing agents.

Preparation method of phenoxycarboxylic ester

The invention provides a preparation method of phenoxycarboxylic ester, comprising the following step: a phenolic compound and hydroxycarboxylic ester react under the action of a catalyst to obtain phenoxycarboxylic ester, wherein the catalyst is one or more of protonic acid, solid acid and a supported catalyst. By using the phenolic compound and hydroxycarboxylic ester as the raw materials, the reaction is carried out in a chloride-free nonmetallic ion system, and generation of high salinity wastewater and metal chloride by-product is completely eradicated. Therefore, washing brine is saved,and wastewater quantity is greatly reduced. The wastewater quantity is reduced from original at least 25 tons to 82 kg for one ton of the product. According to the invention, the technological processis simplified, loss of active ingredients is reduced, yield of active ingredients is increased, and product purity is high. Meanwhile, the method is convenient for continuous production, production period is short, and raw materials are easily available. Therefore, the production cost is reduced.

Regioselective Alkoxycarbonylation of Allyl Phenyl Ethers Catalyzed by Pd/dppb under Syngas Conditions

A simple and regioselective synthesis of phenoxy esters and phenylthio esters is reported. The products are obtained by selective alkoxycarbonylation catalyzed by Pd2(dba)3, 1,4-bis(diphenylphisphino)butane (dppb), and syngas (CO/H2) in chloroform/alcohol. This methodology affords bifunctional products in good yield with excellent n-selectivity and without the need to use additives.

COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS

The present invention provides delivery agent compounds, compositions containing delivery agent compounds and an active agent and methods for delivering active agents, such as biologically or chemically active agents.