999-10-0Relevant academic research and scientific papers
Synthetic method of aminothiazole compounds
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Paragraph 0085-0089, (2020/09/09)
The invention provides a synthetic method of aminothiazole compounds, and belongs to the technical field of medicine synthesis. The synthetic method comprises the following steps: step f, reacting a compound with a structure as shown in a formula (VI) with selenium dioxide to obtain a compound with a structure as shown in a formula (VII) and the like. The synthetic method of the aminothiazole compound is mainly used for synthesizing the aminothiazole compound, is easy to operate, simple in post-treatment, mild in reaction condition and high in final product yield.
Hydrogenation of γ-Butyrolactone to 1,4-Butanediol over CuCo/TiO2 Bimetallic Catalysts
Huang, Zhiwei,Barnett, Kevin J.,Chada, Joseph P.,Brentzel, Zachary J.,Xu, Zhuoran,Dumesic, James A.,Huber, George W.
, p. 8429 - 8440 (2017/12/08)
Titania-supported monometallic and bimetallic Cu-Co catalysts were prepared using (co)impregnation and studied for the hydrogenation of γ-butyrolactone (GBL) to 1,4-butanediol (BDO) at temperatures from 100 to 180 °C and a hydrogen pressure of 3.4 MPa. The highest catalytic activity occurred at a Cu:Co atomic ratio of 1:9 (Cu0.1Co0.9/TiO2), and a 95% yield of BDO was obtained. Characterization results showed mainly small nanoparticles (average size 2.6 nm) for pure Cu/TiO2, large particles (～19.8 nm) for pure Co/TiO2, and a bimodal particle size distribution of both small (～2.3 nm) and large (～16.5 nm) particles for the bimetallic catalyst with a Cu:Co ratio of 1:1. The addition of ～10 mol % Cu to Co/TiO2 increased the reducibility of the Co and resulted in the formation of core-shell CuCo bimetallic nanoparticles with a Co-rich core and Cu-rich shell. GBL hydrogenation in liquid ethanol and water produced an ester (ethyl 4-hydroxybutanoate) and a carboxylic acid (4-hydroxybutanoic acid) as the major products, respectively. GBL hydrogenation in 1,4-dioxane likely went through a 2-hydroxytetrahydrofuran (2-HTHF) intermediate. The 2-HTHF underwent facile ring-opening tautomerization to 4-hydroxybutanal (4-HB), followed by rapid hydrogenation to BDO at a reaction rate up to 700 times faster than GBL hydrogenation. The Cu0.1Co0.9/TiO2 catalyst maintained the BDO selectivity and about 80% of initial activity for GBL hydrogenation after 150 h time on stream in a continuous flow reactor.
HERBICIDAL ISOXAZOLO[5,4-B]PYRIDINES
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Page/Page column 58, (2013/07/25)
The invention relates to isoxazolo[5,4-b]pyridine compounds of formula (I), to the agriculturally useful salts of isoxazolo[5,4-b]pyridine compounds of formula (I), and to their use as herbicides.
Oxidation of cyclic acetals by ozone in ionic liquid media
Van Doorslaer, Charlie,Peeters, Annelies,Mertens, Pascal,Vinckier, Chris,Binnemans, Koen,De Vos, Dirk
experimental part, p. 6439 - 6441 (2010/03/04)
The application of ozone-stable pyrrolidinium based ionic liquids as safe reaction media resulted in selective hydroxy ester formation upon ozonation of cyclic acetals without using low temperatures or acetylating reagents.
SULFONAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF
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Page/Page column 77-78, (2008/12/04)
The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula (I), as defined in the specification. The invention is also directed to compositions containing the compounds of formula (I).
Trimethylaluminum (TMA)-catalyzed reaction of alkynyllithiums with ethylene oxide: Increased yields and purity of homopropargylic alcohols
Brummond, Kay M.,McCabe, Jamie M.
, p. 2457 - 2460 (2007/10/03)
An efficient protocol was developed to obtain homopropargylic alcohols. Subjecting alkynyllithiums and ethylene oxide to 10-20 mol% of trimethylaluminum provided homopropargylic alcohols in good yields. Georg Thieme Verlag Stuttgart.
Relative rate profile for ring-closing metathesis of a series of 1-substituted 1,7-octadienes as promoted by a 4,5-dihydroimidazol-2-ylidene-coordinated ruthenium catalyst
Guo, Xin,Basu, Kallol,Cabral, Jose A.,Paquette, Leo A.
, p. 789 - 792 (2007/10/03)
(Matrix presented) This report details the kinetic responses of nine compounds of type 6 to ring-closing metathesis as promoted by 2 to give the identical product 7. The experimental observations have been subjected to Hammett analysis. The ρ value for the composite aromatic derivatives (R = p-XC6H4-) differs from that of the aliphatic series, although both are negative because electron-donating groups accelerate the reaction.
Selective deprotection of isopropyl esters, carbamates and carbonates with aluminum chloride
Chee
, p. 1593 - 1595 (2007/10/03)
The O-isopropyl bond of isopropyl esters, carbamates, and carbonates has been effectively and selectively cleaved by treatment with AlCl3 in nitromethane at 0-50 °C to give carboxylic acids, amines, and alcohols, respectively, in good to excell
Enantiomerically pure tetrahydro-5-oxo-2-furancarboxylic esters from dialkyl 2-oxoglutarates
Drioli, Sara,Nitti, Patrizia,Pitacco, Giuliana,Tossut, Laura,Valentin, Ennio
, p. 2713 - 2728 (2007/10/03)
Enantiomerically pure tetrahydro-5-oxo-2-furancarboxylic esters can be prepared either by enzymatic resolution of the racemic γ-lactones themselves or by bioreduction with baker's yeast of dialkyl 2-oxoglutarates and subsequent cyclization of the resulting dialkyl 2-hydroxyglutarates. The best results were obtained by the former route, by which the desired compounds were isolated in high enantiomeric excess. Bioreductions were less satisfactory. In fact the hydroxyester intermediates were initially formed as racemic mixtures and their final enantiomeric enrichment was reached by asymmetric destruction, occurring in the bioreaction medium, however at the same time large amounts of alkyl 4-hydroxybutanoates were formed as side products.
Condensed benzazepine derivative and pharmaceutical composition thereof
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, (2008/06/13)
This invention relates to nitrogen-containing aromatic 5-membered ring-condensed benzazepine derivatives represented by the general formula (I) STR1 (symbols in the formula have the following meanings; ring B: a nitrogen-containing aromatic 5-membered ring having at least 1 nitrogen atom and optionally one oxygen or sulfur atom, which may optionally have substituent(s), R1 and R2 : these may be the same or different from each other and each represents a hydrogen atom, a halogen atom, a lower alkyl group, an amino group which may optionally be substituted by lower alkyl group(s), or a lower alkoxy group, A: a single bond; a group represented by the formula n: 0 or an integer of from 1 to 3, R3 and R4 : these may be the same or different from each other and each represents a hydrogen atom, a lower alkyl group (provided that R3 and R4 may together form a lower alkylene group having 2 to 7 carbon atoms), and ring C: a benzene ring which may optionally have substituent(s)) and salts thereof; to pharmaceutical compositions which contain these compounds as an active ingredient and to intermediates which are useful in synthesizing these compounds. The compounds of this invention are useful as arginine vasopressin antagonists.
