1111265-88-3

Basic information

• Product Name: C₂₈H₃₀FN₉OS
• CAS NO: 1111265-88-3
• Molecular Weight: 559.67
• Mol File: 1111265-88-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₈H₃₀FN₉OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₃₀FN₉OS(1111265-88-3)
• EPA Substance Registry System: C₂₈H₃₀FN₉OS(1111265-88-3)

Safety Data

• Hazardous Substances Data: 1111265-88-3(Hazardous Substances Data)

Upstream product

• 1376769-51-5 C₃₁H₄₆N₈O₃SSi 
• 1094070-67-3 C₁₂H₁₀IN₅O₂S 
• 100-82-3 (3-fluorophenyl)methanamine 
• 1111395-07-3 C₂₁H₂₄N₈O₂S 
• 1094070-69-5 C₁₇H₂₂IN₅O₂SSi 
• 1094070-68-4 C₁₈H₂₄IN₅O₃SSi 
• 1094071-87-0 C₈H₈IN₃O₂S 
• 1094070-47-9 C₈H₈IN₃S 
• 1094070-46-8 C₈H₉N₃S 
• 887475-71-0 6-bromo-8-methylsulfanyl-imidazo[1,2-a]pyrazine 

Relevant articles and documents

Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity

The structure-activity relationships of new Aurora A/B kinase inhibitors derived from the previously identified kinase inhibitor 12 are described. Introduction of acetic acid amides onto the pyrazole of compound 12 was postulated to influence Aurora A/B selectivity and improve the profile against off-target kinases. The SAR of the acetic acid amides was explored and the effect of substitution on enzyme inhibition as well as mechanism-based cell activity was studied. Additionally, several of the more potent inhibitors were screened for their off-target kinase selectivity.