35878-28-5

Basic information

• Product Name: CYCLOPENTANE-1,2-DICARBOXYLIC ACID ANHYDRIDE
• Synonyms: 3aα,5,6,6aα-Tetrahydro-1H-cyclopenta[c]furan-1,3(4H)-dione;cis-tetrahydro-1H-cyclopenta[c]furan-1,3(3aH)-dione;cis-cyclopentane-1,2-dicarboxylic anhydride;1H-Cyclopenta[c]furan-1,3(3aH)-dione,tetrahydro-, (3aR,6aS)-rel-;cis-1,2-Cyclopentanedicarboxylic anhydride >=97.0% (GC);cis-Cyclopentane-1,2-dicarboxylic acid anhydride;cis-Tetrahydro-1H-cyclopenta[c]furan-1,3(3aH);CYCLOPENTANE-1,2-DICARBOXYLIC ACID ANHYDRIDE
• CAS NO: 35878-28-5
• Molecular Formula: C₇H₈O₃
• Molecular Weight: 140.14
• EINECS: 252-773-0
• Mol File: 35878-28-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 73-74 °C
• Boiling Point: 84-86°C/0.5mm
• Flash Point: 140.371 °C
• Appearance: /
• Density: 1.31 g/cm³
• Refractive Index: 1.555
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• BRN: 12396898
• CAS DataBase Reference: CYCLOPENTANE-1,2-DICARBOXYLIC ACID ANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOPENTANE-1,2-DICARBOXYLIC ACID ANHYDRIDE(35878-28-5)
• EPA Substance Registry System: CYCLOPENTANE-1,2-DICARBOXYLIC ACID ANHYDRIDE(35878-28-5)

Safety Data

• Hazard Codes: Xi
• Statements: 38-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 35878-28-5(Hazardous Substances Data)

Usage

Uses

cis-1,2-Cyclopentanedicarboxylic Anhydride functions as a reagent in the enantioselective synthesis of disubstituted proline derivatives and its application in synthesis of hepatitis C virus protease inhibitor telaprevir, Nrf2-Keap1 complex inhibitors preparation, binding mode and structural-activity relationship.

InChI:InChI=1/C14H18O7/c15-11(16)7-3-1-5-9(7)13(19)21-14(20)10-6-2-4-8(10)12(17)18/h7-10H,1-6H2,(H,15,16)(H,17,18)/t7-,8+,9+,10-

Upstream product

• 80656-14-0 trans-1,2-cyclopentanedicarboxylic acid 
• 21917-20-4 (trans)-1,2-cyclopentanedicarboxylic acid 
• 118577-36-9 ethyl 5-bromo-2-oxocyclohexanecarboxylate 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 
• 30132-23-1 ethyl 3-bromo-2-oxocyclohexanecarboxylate 
• 90474-13-8 diethyl cyclopentane-1,2-dicarboxylate 
• 1461-96-7 cis-1,2-cyclopentanedicarboxylic acid 
• 50483-99-3 trans-DL-1,2-cyclopentanedicarboxylic acid 

Downstream Products

• 40482-10-8 2-carbamoylcyclopentanecarboxylic acid 
• 75658-83-2 cis-1,2-bis(hydroxymethyl)cyclopentane 
• 648433-16-3 (1S,2R)-cis-2-benzyloxycarbonyl-cyclopentane-1-carboxylic acid 
• 198022-67-2 (1R,2S)-Cyclopentane-1,2-dicarboxylic acid mono-((E)-3-phenyl-allyl) ester 
• 88315-64-4 (1S,2R)-cis-2-methoxycarbonyl-cyclopentane-1-carboxylic acid 
• 88335-90-4 (1R,2S)-cis-2-methoxycarbonyl-cyclopentane-1-carboxylic acid 
• 111939-08-3 N-benzyl-3-azabicyclo[3.3.0]octane-2,4-dione 
• 4841-91-2 dimethyl cis-1,2-cyclopentanedicarboxylate 
• 151710-39-3 N-(4-methoxyphenyl)-cis-cyclopentane-1,2-dicarboximide 
• 1461-96-7 cis-1,2-cyclopentanedicarboxylic acid 

Relevant articles and documents

NOVEL HEPATITIS C VIRUS INHIBITORS

The invention provides compounds of formula (I): wherein Rings A and A' are independently 5-membered optionally substituted aromatic heterocycles; Q is C(=O)NR1R1' or formula U is C(R4)2, O, S, S(=O)2, C(R4)2C(R4)2, CH2O, OCH2, CH2S, SCH2, CH2S(=O)2, S(=O)CH2 or C=C(Ru )2; X is CH2, CHR12, CR12R12, O, S, S(=O)2 or NRx; m is 0, 1, 2 or 3; n is 0, 1, 2 or 3; the other variables are as defined in the claims, which are of use in the treatment or prophylaxis of hepatitis C virus infection, and related aspects.

Ruthenium(salen)-catalyzed aerobic oxidative desymmetrizatin of meso-diols and its kinetics

Chiral (nitrosyl)ruthenium(salen) complexes were found to be efficient catalysts for aerobic oxidative desymmetrization of meso-diols under photoirradiation to give optically active tactols. The scope of the applicability of this reaction ranges widely from acyclic diols to mono-cyclic diols, although fine ligand-tuning of the ruthenium(salen) complexes was required to attain high enantioselectivity (up to 93% ee). In particular, the nature of the apical ligand was found to affect not only enantioselectivity but also kinetics of the desymmetrization reaction. Spectroscopic analysis of the oxidation disclosed that irradiation of visible light is indispensable not only for dissociation of the nitrosyl ligand but also for single electron transfer from the alcohol-bound ruthenium ion to dioxygen.

Synthesis of cyclooctenones using intramolecular hydroacylation

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