111184-83-9

Upstream product

• 95-14-7 1,2,3-Benzotriazole 
• 50-00-0 formaldehyd 
• 100-46-9 benzylamine 
• 28539-02-8 1-Hydroxymethyl-1H-benzotriazole 

Downstream Products

• 1026-59-1 (rac)-N-benzyl-3-phenylpyrrolidine 
• 4209-77-2 1-benzyl-3,4-diphenylpyrrolidine 
• 220474-60-2 1-benzyl-3-(4'-fluorophenyl)pyrrolidine 
• 109105-86-4 N-benzyl-4-methylenepiperidine 
• 127073-78-3 1-benzyl-4-chloro-4-methylpiperidine 
• 67848-71-9 4-chloro-1-benzylpiperidine 
• 188257-30-9 5-benzyl-5,6-dihydro-4H-1,3,5-dithiazine 
• 128307-70-0 3-benzyl-3,4-dihydro-2H-benzo[e][1,3]oxazine 
• 1448049-61-3 (E)-N-benzyl-N-(2,3-dimethyl-3-butenyl)-3-methyl-3-pentenylamine 

Relevant academic research and scientific papers

Benzotriazole mediated synthesis of some 5-alkyl-dihydro-4H-1,3,5- dithiazines

An efficient synthesis of N-substituted dihydro-4H-1,3,5-dithiazines is described. N,N-Bis(benzotriazolylmethyl)alkylamines 1 smoothly under go cyclisation reaction in the presence of formaldehyde and hydrogen sulfide to give 5-substituted dihydro-4H-1,3,5-dithiazines 2.

Synthesis of 3,4-dihydro-2H-1,3,5-thiadiazines

3,4-Dihydro-2H-1,3,5-thiadiazines substituted at the 3 and 6 positions were synthesized by treatment of N-substituted N,N-bis(1H-1,2,3-benzotriazol-1-ylmethyl)-amines with thioamides and zinc bromide in dry CH2Cl2 at room temperature for 48-60 h in 48-80% yields.

Reactions of Benzotriazole with Formaldehyde and Aliphatic Primary Amines: Selective Formation of 1:1:1, of 2:2:1, and of 2:3:2 Adducts and a Study of their Reactions with Nucleophiles

Benzotriazole (BtH) reacts easily with aliphatic primary amines and formaldehyde in aqueous media to give one or more of three types of product: (i) (BtCCH2)2NR (5), (ii) (BtCH2NR)2CH2 (6), and/or (iii) BtCH2NHR (7).The product formed depends on the molar

The Chemistry of Benzotriazole. Part 3. The Aminoalkylation of Benzotriazole

1-(1-Hydroxyalkyl)benzotriazoles convert a wide variety of aromatic and heteroaromatic primary amines into their mono N- derivatives in high yield.Aliphatic primary amines frequently give bis-derivatives.Product structure is established by 13C n.m.r.; dangers in the use of 1H n.m.r. to distinguish 1- and 2-substituted benzotriazoles are pointed out.