111248-45-4

Upstream product

• 123-75-1 pyrrolidine 
• 111248-38-5 phenylthioacetaldehyde cyanohydrin acetate 
• 5296-21-9 2-(phenylsulfanylmethyl)oxirane 
• 108-98-5 thiophenol 
• 5149-48-4 3-(phenylthio)-1,2-propanediol 
• 66303-55-7 2-(phenylthio)acetaldehyde 
• 151-50-8 potassium cyanide 

Downstream Products

• 111248-38-5 phenylthioacetaldehyde cyanohydrin acetate 
• 111248-42-1 2-Diethylamino-3-phenylsulfanyl-propionitrile 
• 111248-09-0 1-(Dimethylamino)-2-(phenylthio)ethylene 

Relevant academic research and scientific papers

Formation of Optically Active Aryloxyacetaldehyde Cyanohydrin Acetates with the Aid of a Microorganism

Microorganisms that hydrolyze the one enantiomer of dl-phenoxyacetaldehyde cyanohydrin acetate were screened, and Bacillus coagulans isolated from soil was found to be the best.This bacterium was applied to the asymmetric hydrolysis of other aryloxyacetaldehyde derivatives to give satisfactory results.The effect of adding dimethyl sulfoxide to the medium is also described.

A Formylcarbonium Ion Synthon. Synthesis of 3-Thio-Substituted 2-Amino Acids and Thio-Substituted Enamines from 2-Acyloxyacrylonitriles

The utilization of 2-acyloxy-3-phenylthiopropionitriles (2) which were prepared by the Michael addition of thiophenol to 2-acyloxyacrylonitriles (CH2=C(CN)OCOR), as a formylcarbonium ion synthon, was demonstrated by the transformation of 2 into S-phenylcysteine and 2-phenylthio enamines.