5149-48-4

Usage

InChI:InChI=1/C9H12O2S/c10-6-8(11)7-12-9-4-2-1-3-5-9/h1-5,8,10-11H,6-7H2

Upstream product

• 110210-93-0 2-hydroxy-3-phenylthiopropyl acetate 
• 4704-77-2 1-bromo-2,3-propanediol 
• 108-98-5 thiophenol 
• 5296-64-0 allyl phenyl thioether 
• 66003-76-7 Diphenyliodonium triflate 
• 56-81-5 glycerol 
• 556-52-5 oxiranyl-methanol 
• 93-14-1 guaifenesin 
• 14007-09-1 2-(2-methoxyphenoxy)-1,3-propanediol 
• 3111-52-2 potassium thiophenolate 
• 96426-73-2 Glycidyl N,N-dimethylcarbamate 
• 13318-11-1 2-((4-nitrobenzoyloxy)methyl)oxirane 
• 5296-21-9 2-(phenylsulfanylmethyl)oxirane 
• 584-07-6 methyl N-hydroxycarbamate 

Downstream Products

• 5149-50-8 Benzenesulfinyl-acetaldehyde 
• 27098-65-3 3-phenylsulfanyl-propionaldehyde 
• 66303-55-7 2-(phenylthio)acetaldehyde 
• 111248-38-5 phenylthioacetaldehyde cyanohydrin acetate 
• 111248-45-4 2-(phenylthio)acetaldehyde cyanohydrin 
• 38513-17-6 1-Phenylsulfonyl-3-prop-1-enyl-methansulfonat 
• 143945-89-5 3-benzenesulfonyl-propane-1,2-diol 

Relevant academic research and scientific papers

One-pot catalyst-free synthesis of β-and γ-hydroxy sulfides using diaryliodonium salts and microwave irradiation

A simple and rapid one-pot protocol is described for the preparation of α- and β-hydroxy sulfides. The direct solvent-free microwave irradiation of diaryliodonium salts, potassium thiocyanate, and ethylene glycol/β-propylene glycol without any catalyst or base affords the final compounds in good yields (65-95 %) in around 10-25 min. Copyright

Stereo- and regioselective thiolysis of 1,2-epoxides in water

A simple, efficient, stereoselective, and highly regioselective procedure for the synthesis of β-hydroxy sulfides by thiolysis of various 1,2-epoxides in water as a solvent, using no catalyst and under very mild conditions, is described. Copyright Taylor

Method for the dihydroxylation of olefins using transition metal catalysts

This invention relates to process for dihydroxylation of olefins using transition metal catalysts to obtain monofunctional, bifunctional, and/or polyfunctional 1,2-diols of the formula (I) R1R2C(OH)—C(OH)R3R4??(I) where R1to R4are defined herein, by reacting an olefin of the formula (II) R1R2C═CR3R4??(II) where R1to R4are defined as for formula (I), with molecular oxygen in the presence of an osmium, ruthenium, or manganese compound in water or a water-containing solvent mixture at a pH of from 7.5 to 13.

ZnCl2 as an Efficient Catalyst in the Thiolysis of 1,2-Epoxides by Thiophenol in Aqueous Medium

ZnCl2 (5 mol%) is an efficient catalyst for the thiolysis of 1,2-epoxides by thiophenol in water at pH 4.0. A variety of β-hydroxy phenylsulfides were obtained in short reaction times and excellent yields. Starting from cyclohexene oxide (1), two one-pot multi-step procedures in sole water (thiolysis/oxidation with H2O2) have been realized, for the chemoselective synthesis of the corresponding β-hydroxysulfoxides 19 or for the related β-hydroxysulfone 20.

Naphthyloxy acetic acid derivatives and a pharmaceutical composition comprising them as an active ingredient

The naphthyloxyacetic acid derivatives of the formula (I) wherein A is H, -(alkylene)COOR1, -(alkylene)CONR2R3, -(alkylene)OH, -(alkylene)tetrazole, -(alkylene)CN; E is single bond or alkylene; G is —S—, —SO—, —SO2—, —O— or —NR4—; L is alkylene, —(CH2)m—CH═CH—(CH2)n— or —(CH2)x—CH(OH)—(CH2)y—; M is phenyl, phenyl(thio, oxy, amino), diphenylmethyl, diphenylmethyl(thio, oxy, amino), and pharmaceutical composition comprising them as an active ingradient. The compounds of the formula (I) can combine PGE2receptor and exhibit the activity to antagonize or agonize for PGE2receptor. Therefore, they are useful as anti-hyperlipemia, for the prevention of abortion, for analgesics, as antidiarrheals, sleep inducer, diuretic, anti-diabetes, abortient, cathartics, antiulcer, anti-gastritis or antihypertensive etc.

Facile synthesis of vinyl sulfones from β-bromo alcohols

Vinyl sulfones are synthesized in good yields by dehydration of β- hydroxy sulfones derived from β-bromo alcohols.

Osmium-Catalyzed Dihydroxylation of Olefins Using Dioxygen or Air as the Terminal Oxidant

The osmium-catalyzed dihydroxylation of various olefins using molecular oxygen or air as the stoichiometric oxidant is reported. Aromatic olefins yield the corresponding diols in good to excellent chemoselectivities under optimized pH conditions (pH = 10.4-12.0). Air can be used under moderate pressures (3-9 bar) instead of dioxygen as the reoxidant. By increasing the oxygen content of the solution, it is possible to achieve highly efficient conversion at low catalyst amount (catalyst/substrate = 1:4000). Tri- and tetrasubstituted olefins are oxidized at pH > 11 to give the corresponding 1,2-diols in good to very good yields without requiring the addition of sulfonamides or other hydrolysis agents. Studies of the dihydroxylation of functionalized olefins demonstrate that the reaction conditions tolerate a variety of functional groups. In the presence of dihydroquinine or dihydroquinidine derivatives (Sharpless ligands), asymmetric dihydroxylations occur with lower enantioselectivities than tose of the classical K3[Fe(CN)6] reoxidation system.

Dihydroxylation and oxidative cleavage of olefins in the presence of sulfur

The dihydroxylation of olefins using AD-mix or OsO4/K3Fe(CN)6 in the presence of sulfides has been examined as has the rate of oxidation of various classes of sulfides. The selectivity of olefin oxidation in preference to sulfur oxidation depends on the nature of the sulfur moiety, and can be problematic for certain classes of substrates.

FUNCTIONALLY SUBSITUTED SULFUR-CONTAINING COMPOUNDS. 9. REASTIONS OF 2-OXIRANES WITH ACETIC ANHYDRIDE AND ACETYL CHLORIDE

Reaction of 2-oxiranes with acetic anhydride gives a mixture of 3-(organylthio)-1,2-diacetoxypropane and 2-(organylthio)-1,3-diacetoxypropane, and with acetyl chloride a mixture of 2-chloro-3-(organylthio)-1-acetoxypropane and 3-chloro-2-(organylthio)-1-acetoxypropane.In both cases, the ratio of the isomers depends on the nature of the organylthio group and on the nature of the electrophile.

Formation of Optically Active Aryloxyacetaldehyde Cyanohydrin Acetates with the Aid of a Microorganism

Microorganisms that hydrolyze the one enantiomer of dl-phenoxyacetaldehyde cyanohydrin acetate were screened, and Bacillus coagulans isolated from soil was found to be the best.This bacterium was applied to the asymmetric hydrolysis of other aryloxyacetaldehyde derivatives to give satisfactory results.The effect of adding dimethyl sulfoxide to the medium is also described.