1112982-76-9

Usage

Uses

Used in Pharmaceutical Industry:
N-(5-Bromothiazolo[5,4-b]pyridin-2-yl)acetamide is used as a pharmaceutical intermediate for the synthesis of various pharmaceutical drugs. Its unique chemical structure and properties make it a key component in the development of medications that target a range of health conditions.
Used in Medication Development:
In the field of medication development, N-(5-Bromothiazolo[5,4-b]pyridin-2-yl)acetamide is employed as a building block for creating new therapeutic agents. Its incorporation into drug molecules can enhance their efficacy, selectivity, and safety profiles, contributing to the advancement of novel treatments for various diseases and disorders.

Upstream product

• 13250-46-9 acetyl isothiocyanate 
• 169833-70-9 6-bromo-2-chloropyridine-3-ylamine 
• 934266-82-7 5-bromothiazolo[5,4-b]pyridin-2-amine 
• 108-24-7 acetic anhydride 
• 39856-57-0 2,6-dibromo-3-aminopyridine 

Downstream Products

• 1112980-79-6 N-(5-(3-aminophenyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)acetamide 
• 934266-82-7 5-bromothiazolo[5,4-b]pyridin-2-amine 
• 1616589-57-1 5-(2-acetamidothiazolo[5,4-b]pyridin-5-yl)-3-(4-fluorophenylsulfonylamino)-2-methoxybenzamide 

Relevant academic research and scientific papers

Combination of 2-methoxy-3-phenylsulfonylaminobenzamide and 2-aminobenzothiazole to discover novel anticancer agents

The fragment of 2-substituted-3-sulfonylaminobenzamide has been proposed to replace the fragment of 2-substituted-3-sulfonylaminopyridine in PI3K and mTOR dual inhibitors to design novel anticancer agents based on bioisostere. The combination of the fragm

PI3K/M TOR INHIBITORS

The invention relates to PI3K/mTOR inhibiting compounds consisting of the formula (I): wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; meth

INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE

The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K ggr;. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

PI3 KINASE MODULATORS AND METHODS OF USE

The present invention comprises a new class of compounds capable of modulating the activity of PI3 kinase and, accordingly, useful for treatment of PI3 kinase mediated diseases, including melanomas, carcinomas and other cancer-related conditions. The compounds have a general Formula I wherein each of A1, A2, A3, A4, X, R1 and R2 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of PI3 kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.