1113-70-8

Upstream product

• 156-87-6 propan-1-ol-3-amine 
• 79-50-5 pantolactone 
• 79-50-5 (S)-pantolactone 
• 50584-68-4 panthenol 
• 599-04-2 (R)-Pantolacton 

Downstream Products

• 94089-18-6 D-panthenol triacetate 
• 98133-47-2 Panthenol-triacetat 
• 32484-53-0 C₁₁H₂₁NO₅ 
• 1194728-05-6 C₁₃H₂₃NO₆ 

Relevant academic research and scientific papers

Determination of panthenol enantiomers in cosmetic preparations using an achiral-chiral–coupled column HPLC system

A new high-performance liquid chromatography (HPLC) method for separation and determination of panthenol enantiomers in hair care products was developed. Two types of detectors, low-wavelength ultraviolet (UV) and polarimetric, were used. Optimized conditions consisted of coupled achiral, amino type, and chiral, amylose tris(3,5-dimethylphenylcarbamate), stationary phases, mixture of n-hexane/ethanol (60:40, v/v) as mobile phase under isocratic conditions and flow rate 0.8 cm3 min?1. The effect of column temperature on retention and resolution of enantiomers was studied. The analysis runtime was 10 minutes, and the average retention times for d- and l-panthenol were 7.10 ±0.1 minutes and 8.21 ±0.2 minutes, respectively. The resolution of enantiomers on coupled achiral-chiral columns was Rs = 2.7. The solid-phase extraction method was employed for extraction and purification of analytes. The validated method was selective, accurate, and linear (R2 >.998) over the concentration range of 0.001 to 1.0 mg cm?3 for both enantiomeric forms. The limits of detection (LOD) and quantitation (LOQ) of each enantiomer were 0.3 and 1.0 μg cm?3, respectively. The results demonstrated the occurrence of d-panthenol in hair care products.

ALPHA HYDROXY AMIDES

The present invention relates to alpha hydroxy amides including compounds of formula (I) and related compounds and their use in the prophylaxis and treatment of inflammatory disorders and diseases, wherein T1, T2, W and Rw has the meaning given in claim 1.

PROCESS FOR PREPARING AND PURIFYING 3-AMINOPROPANOL

The present invention relates to a process for purifying a reaction output which comprises 3-aminopropanol and is obtained in the reaction of ethylene cyanohydrin with hydrogen in the presence of ammonia, which comprises distilling the reaction output comprising 3-aminopropanol in two or more stages, the ammonia content of the reaction output comprising 3-aminopropanol before introduction into the first distillation stage being 1% by weight or less and the temperature in the distillation stages being not more than 135° C. The invention further relates to a process for preparing 3-aminopropanol by reacting ethylene cyanohydrin with hydrogen in the presence of ammonia, which comprises performing the purification of the reaction output comprising 3-aminopropanol in accordance with the invention. The present invention further provides a process for preparing 3-aminopropanol derivatives, especially panthenol, acambrosate, mefenorex, domperidon, ifosamid or urapidil, from 3-amino-propanol prepared in accordance with the invention.

Method For the Production of a Keratin-Binding Effector Molecule

The invention relates to a method of producing keratin-binding effector molecules, and to intermediates and end-products of the method according to the invention and to the use of the keratin-binding effector molecules produced according to the invention in dermocosmetics. In addition, the invention relates to a method of applying dermocosmetically active ingredients to skin and/or hair and to a method of increasing the residence time of an active ingredient on skin and hair.