1113-74-2

Basic information

• Product Name: 2,4-dimethylpentan-3-one oxime
• Synonyms: 2,4-dimethylpentan-3-one oxime;2,4-Dimethyl-3-pentanone oxime;2,4-Dimethylpentane-3-one oxime;Diisopropyl ketoneoxime;3-Pentanone, 2,4-dimethyl-, oxime;MFCD00182586;N-(2,4-dimethylpentan-3-ylidene)hydroxylamine
• CAS NO: 1113-74-2
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.2001
• EINECS: 214-208-6
• Mol File: 1113-74-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: 34°C
• Boiling Point: 239.29°C (rough estimate)
• Flash Point: 98.8°C
• Appearance: /
• Density: 0.9022
• Vapor Pressure: 0.199mmHg at 25°C
• Refractive Index: 1.4419 (estimate)
• CAS DataBase Reference: 2,4-dimethylpentan-3-one oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dimethylpentan-3-one oxime(1113-74-2)
• EPA Substance Registry System: 2,4-dimethylpentan-3-one oxime(1113-74-2)

Safety Data

• Hazardous Substances Data: 1113-74-2(Hazardous Substances Data)

Usage

General Description

2,4-dimethylpentan-3-one oxime is a chemical compound that belongs to the oxime class of compounds. It is a derivative of the ketone 2,4-dimethylpentan-3-one and is commonly used in industrial applications as a chelating agent and as a building block for the synthesis of other organic compounds. It is also used in the manufacturing of pharmaceuticals and agricultural products. 2,4-dimethylpentan-3-one oxime is known for its ability to complex with metal ions, making it useful in various chemical processes and applications. It is important to handle 2,4-dimethylpentan-3-one oxime with caution due to its potential hazard on human health and the environment.

InChI:InChI=1/C7H15NO/c1-5(2)7(8-9)6(3)4/h5-6,9H,1-4H3

Upstream product

• 681856-03-1 2,4-dimethylpentan-3-one-O-(phenylmethyl)oxime 
• 108-08-7 2,4-dimethylpentane 
• 565-80-0 2,4-dimethylpentan-3-one 

Downstream Products

• 78-82-0 Isobutyronitrile 
• 187737-37-7 propene 
• 565-80-0 2,4-dimethylpentan-3-one 
• 681856-03-1 2,4-dimethylpentan-3-one-O-(phenylmethyl)oxime 
• 4108-82-1 1-<2.4-Dimethyl-pentyl-(3)>-3.3-diphenyl-harnstoff 
• 72357-06-3 N-benzyl-N-(2,4-dimethylpent-2-en-3-yl)acetamide 
• 1644662-20-3 ethyl 2-benzyl-2-{[(2,4-dimethylpentan-3-ylidene)amino]oxy}-3-oxobutanoate 
• 869-07-8 N-isopropylisobutyramide 
• 74021-68-4 2,4-Dimethylpentan-3-onoxim O-(p-nitrophenyl)ether 
• 53443-42-8 C₁₅H₁₉Cl₂NO₃ 
• 53443-02-0 C₁₇H₂₄ClNO₃ 
• 53443-24-6 C₁₆H₂₁Cl₂NO₃ 
• 53442-89-0 C₁₆H₂₂ClNO₃ 
• 4083-57-2 2,4-dimethylpent-3-ylamine 

Relevant articles and documents

Novel cis- and trans-configured bis(oxime)platinum(II) complexes: Synthesis, characterization, and cytotoxic activity

Novel cis- and trans-configured bis(oxime)platinum(II) complexes have been synthesized and characterized by elemental analyses, IR, electrospray ionization mass spectrometry, multinuclear (1H, 13C, and 195Pt) NMR spectroscopy, and, in five cases, by X-ray diffraction. Their cytotoxicity was studied in the cisplatin-sensitive CH1 cell line as well as in inherently cisplatin-resistant SW480 cancer cells. Remarkably, every single dihalidobis(oxime)platinum(II) complex (with either a cis or trans configuration) shows a comparable cytotoxic potency in both cell lines, indicating a capacity of overcoming cisplatin resistance. Particularly strong cytotoxicities were observed in the case of trans-[PtCl2(R 2C=NOH)2] (R = Me, n-Pr, i-Pr) with IC50 values in the high nanomolar concentration range in both CH1 and SW480 cancer cells. These complexes are as potent as cisplatin in CH1 cells and up to 20 times more potent than cisplatin in SW480 cells. In comparison to transplatin, the novel compounds are up to 90 (CH1) and 120 times (SW480) more cytotoxic. The previously reported observation that the trans geometry yields a more active complex in the case of [PtCl2(Me2C=NOH)2] could be confirmed for at least two structural analogues.

Dehydrative Beckmann rearrangement and the following cascade reactions

The Beckmann rearrangement has been predominantly studied for the synthesis of amide and lactam. By strategically using the in situ generated Appel's salt or Mitsunobu's zwitterionic adduct as the dehydrating agent, a series of Beckmann rearrangement and following cascade reactions have been developed herein. The protocol allows the conversion of various ketoximes into amide, thioamide, tetrazole and imide products in modular procedures. The generality and tolerance of functionalities of this method have been demonstrated.

Copper-catalyzed synthesis of thiazol-2-yl ethers from oxime acetates and xanthates under redox-neutral conditions

A novel copper-catalyzed annulation of oxime acetates and xanthates for the synthesis of thiazol-2-yl ethers with remarkable regioselectivity has been developed. Various oxime acetates, whether derived from aryl ketones or alkyl ketones, or natural product cores are suitable for this conversion. Unique dihydrothiazoles were also obtained when both reaction sites were methine. Mechanistic studies indicated that imino copper(iii) intermediates were involved. In addition, this protocol proceeded under redox-neutral conditions and did not require additives or ligands.