111423-15-5

Upstream product

• 100-63-0 phenylhydrazine 
• 16078-71-0 ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate 

Downstream Products

• 61262-32-6 1,5-diphenyl-1,7-dihydro-pyrazolo[3,4-d]pyrimidine-4,6-dione 
• 111423-18-8 5-(2,4-Dimethyl-phenyl)-1-phenyl-1,7-dihydro-pyrazolo[3,4-d]pyrimidine-4,6-dione 
• 111423-13-3 6-(2,4-Dimethyl-phenylamino)-1-phenyl-1H-pyrazolo[3,4-d][1,3]oxazin-4-one 
• 111423-16-6 5-(4-Methoxy-phenyl)-1-phenyl-1,7-dihydro-pyrazolo[3,4-d]pyrimidine-4,6-dione 
• 111423-19-9 5-(3,5-Dimethyl-phenyl)-1-phenyl-1,7-dihydro-pyrazolo[3,4-d]pyrimidine-4,6-dione 
• 111423-17-7 5-(4-Chloro-phenyl)-1-phenyl-1,7-dihydro-pyrazolo[3,4-d]pyrimidine-4,6-dione 
• 61262-34-8 1-phenyl-5-p-tolyl-1,7-dihydro-pyrazolo[3,4-d]pyrimidine-4,6-dione 
• 111423-11-1 6-(4-Methoxy-phenylamino)-1-phenyl-1H-pyrazolo[3,4-d][1,3]oxazin-4-one 
• 111423-12-2 6-(4-Chloro-phenylamino)-1-phenyl-1H-pyrazolo[3,4-d][1,3]oxazin-4-one 
• 111423-10-0 1-Phenyl-6-p-tolylamino-1H-pyrazolo[3,4-d][1,3]oxazin-4-one 

Relevant academic research and scientific papers

Synthesis of 3H-pyrazolo[3,4-c]isoquinolines and thieno[3,2-c]isoquinolines via cascade imination/intramolecular decarboxylative coupling

A general approach for the synthesis of 3H-pyrazolo[3,4-c]isoquinolines and thieno[3,2-c]isoquinolines is described involving the implementation of a cascade imination/intramolecular decarboxylative coupling between potassium 2-amino(hetero)benzoates and 2-haloarylaldehydes. The reactions of pyrazole-based substrates require a Pd-Cu bimetallic system for superior yields whereas the thienyl-based substrates afford the products in excellent yields with a Pd-catalyst only.