111424-64-7Relevant articles and documents
Synthesis of 2,2-Dimethyl-2H-thiochromenes, the Sulfur Analogs of Precocenes
Tercio, J.,Ferreira, B.,Catani, V.,Comasseto, J. V.
, p. 149 - 153 (2007/10/02)
A new general synthesis of 2,2-dimethyl-2H-thiochromenes in good yield consists of the Michael addition of thiophenols to 3-methyl-2-butenoic acid, intramolecular cyclocondensation of the resultant 3-methyl-3-phenylthiobutanoic acids, reduction of the 2,2-dimethyl-4-oxothiochromenes thus obtained with sodium borohydride, and acid-catalyzed dehydration of the resultant 4-hydroxy-2,2-dimethylthiochromans.