52849-52-2

Basic information

• Product Name: 4-BROMO-2-ETHOXY-1-METHOXYBENZENE
• Synonyms: 1-Bromo-3-ethoxy-4-methoxybenzene;4-Bromo-2-ethoxy-1-methoxybenzene;4-Bromo-2-ethoxyanisole
• CAS NO: 52849-52-2
• Molecular Formula: C₉H₁₁BrO₂
• Molecular Weight: 231.1
• Mol File: 52849-52-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 252.08 °C at 760 mmHg
• Flash Point: 100.607 °C
• Appearance: /
• Density: 1.358 g/cm³
• Vapor Pressure: 0.031mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-BROMO-2-ETHOXY-1-METHOXYBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-ETHOXY-1-METHOXYBENZENE(52849-52-2)
• EPA Substance Registry System: 4-BROMO-2-ETHOXY-1-METHOXYBENZENE(52849-52-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 52849-52-2(Hazardous Substances Data)

Usage

General Description

4-BROMO-2-ETHOXY-1-METHOXYBENZENE is a chemical compound with the molecular formula C9H11BrO2. It is a colorless to pale yellow liquid that is insoluble in water but soluble in organic solvents. 4-BROMO-2-ETHOXY-1-METHOXYBENZENE is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used in the production of dyes and pigments. 4-BROMO-2-ETHOXY-1-METHOXYBENZENE is considered to be a hazardous substance and should be handled with care due to its potential to cause skin and eye irritation, as well as respiratory irritation if inhaled.

InChI:InChI=1/C9H11BrO2/c1-3-12-9-6-7(10)4-5-8(9)11-2/h4-6H,3H2,1-2H3

Upstream product

• 90-05-1 2-methoxy-phenol 
• 66037-04-5 1-acetoxy-5-bromo-2-methoxybenzene 
• 613-70-7 2-methoxyphenyl acetate 
• 25016-01-7 5-bromo-2-methoxybenzaldehyde 
• 64-67-5 diethyl sulfate 
• 37942-01-1 5-bromo-2-methoxyphenol 
• 75-03-6 ethyl iodide 

Downstream Products

• 635705-72-5 4-amino-2-[(1S)-1-(3-ethoxy 4-methoxyphenyl)-2-methanesulfonylethyl]-2,3-dihydro-1H-isoindole-1,3-dione 
• 608141-44-2 R-Apremilast 
• 915201-13-7 (3-ethoxy-4-methoxyphenyl)boronic acid 
• 253168-94-4 2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine 
• 608141-42-0 (S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine 
• 608141-43-1 (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate 
• 608141-41-9 Apremilast 
• 111424-50-1 3-(3-Ethoxy-4-methoxy-phenylsulfanyl)-3-methyl-butyric acid 
• 851958-82-2 (4-dimethylamino-phenyl)-(3-ethoxy-4-methoxy-phenyl)-methanol 
• 851958-80-0 (3-ethoxy-4-methoxy-phenyl)-(3-methoxy-phenyl)-methanol 

Relevant articles and documents

Methods for preparation of apremilast

The present invention discloses a method for preparation of Apremilast. β-phthalimino vinylsulfones are reacted through the asymmetric addition reaction to form an addition product, and the drug of Apremilast can be obtained from the addition product through simple reactions. The method is a process for synthesizing Apremilast in a more efficient way.

Asymmetric Synthesis of β-Aryl β-Imido Sulfones Using Rhodium Catalysts with Chiral Diene Ligands: Synthesis of Apremilast

A chiral rhodium(I)-diene catalyst enabled the one-step synthesis of β-aryl β-imido sulfones under mild reaction conditions. By selection of the chiral diene ligand L1a or L2, each enantiomer of the chiral β-aryl β-imido sulfone target can be accessed with high stereoselectivity. Demonstration of the scope of the reaction, which includes the synthesis of an N-protected chiral β-amino β-phenyl sulfone, culminated with the efficient synthesis of the heteroatom-rich active pharmaceutical ingredient apremilast.