52849-52-2

Usage

Uses

Used in Pharmaceutical Industry:
4-BROMO-2-ETHOXY-1-METHOXYBENZENE is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 4-BROMO-2-ETHOXY-1-METHOXYBENZENE serves as an intermediate in the production of agrochemicals. Its involvement in the synthesis process helps create compounds that are essential for crop protection and enhancement of agricultural yields.
Used in Dye and Pigment Production:
4-BROMO-2-ETHOXY-1-METHOXYBENZENE is utilized in the creation of dyes and pigments, where its chemical properties are harnessed to produce a range of colors for various applications, including textiles, plastics, and printing inks.
Given the compound's hazardous nature, it is imperative that safety precautions are strictly adhered to during its production, transportation, and use to minimize the risk of adverse health effects.

InChI:InChI=1/C9H11BrO2/c1-3-12-9-6-7(10)4-5-8(9)11-2/h4-6H,3H2,1-2H3

Upstream product

• 37942-01-1 5-bromo-2-methoxyphenol 
• 75-03-6 ethyl iodide 
• 64-67-5 diethyl sulfate 
• 613-70-7 2-methoxyphenyl acetate 
• 66037-04-5 1-acetoxy-5-bromo-2-methoxybenzene 
• 90-05-1 2-methoxy-phenol 
• 25016-01-7 5-bromo-2-methoxybenzaldehyde 

Downstream Products

• 757962-52-0 (3,5-dimethoxy-phenyl)-(3-ethoxy-4-methoxy-phenyl)-methanol 
• 757962-66-6 (4-methoxy-3-nitro-phenyl)-(3-ethoxy-4-methoxy-phenyl)-methanol 
• 851958-48-0 (3-ethoxy-4-methoxy-phenyl)-(3-fluoro-4-methoxy-phenyl)-methanone 
• 851958-50-4 (3-ethoxy-4-methoxy-phenyl)-(3-pyrrol-1-yl-phenyl)-methanol 
• 851958-52-6 (3-ethoxy-4-methoxy-phenyl)-(4-methoxy-3-methyl-phenyl)-methanol 
• 851958-56-0 (3-benzyloxy-4-methoxy-phenyl)-(3-ethoxy-4-methoxy-phenyl)-methanol 
• 851958-65-1 benzo[1,3]dioxol-5-yl-(3-ethoxy-4-methoxy-phenyl)-methanol 
• 851958-79-7 bis-(3-ethoxy-4-methoxy-phenyl)-methanol 
• 851958-80-0 (3-ethoxy-4-methoxy-phenyl)-(3-methoxy-phenyl)-methanol 
• 851958-82-2 (4-dimethylamino-phenyl)-(3-ethoxy-4-methoxy-phenyl)-methanol 
• 915201-13-7 (3-ethoxy-4-methoxyphenyl)boronic acid 
• 608141-41-9 Apremilast 
• 608141-43-1 (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate 
• 608141-42-0 (S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine 

Relevant academic research and scientific papers

Methods for preparation of apremilast

The present invention discloses a method for preparation of Apremilast. β-phthalimino vinylsulfones are reacted through the asymmetric addition reaction to form an addition product, and the drug of Apremilast can be obtained from the addition product through simple reactions. The method is a process for synthesizing Apremilast in a more efficient way.

Boron Containing PDE4 Inhibitors

The present invention relates to boron containing compounds of Formula (I) [in-line-formulae]X—Y—Z?? Formula (I)[/in-line-formulae] that inhibit phosphodiesterase 4 (PDE4). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating diseases, conditions, or disorders ameliorated by inhibition of PDE4.

Asymmetric Synthesis of β-Aryl β-Imido Sulfones Using Rhodium Catalysts with Chiral Diene Ligands: Synthesis of Apremilast

A chiral rhodium(I)-diene catalyst enabled the one-step synthesis of β-aryl β-imido sulfones under mild reaction conditions. By selection of the chiral diene ligand L1a or L2, each enantiomer of the chiral β-aryl β-imido sulfone target can be accessed with high stereoselectivity. Demonstration of the scope of the reaction, which includes the synthesis of an N-protected chiral β-amino β-phenyl sulfone, culminated with the efficient synthesis of the heteroatom-rich active pharmaceutical ingredient apremilast.

Synthesis of 2,2-Dimethyl-2H-thiochromenes, the Sulfur Analogs of Precocenes

A new general synthesis of 2,2-dimethyl-2H-thiochromenes in good yield consists of the Michael addition of thiophenols to 3-methyl-2-butenoic acid, intramolecular cyclocondensation of the resultant 3-methyl-3-phenylthiobutanoic acids, reduction of the 2,2-dimethyl-4-oxothiochromenes thus obtained with sodium borohydride, and acid-catalyzed dehydration of the resultant 4-hydroxy-2,2-dimethylthiochromans.